Nakamura-Ishizu Ayako
Department of Microscopic and Developmental Anatomy, Tokyo Women's Medical University.
Rinsho Ketsueki. 2024;65(9):872-877. doi: 10.11406/rinketsu.65.872.
Sustaining lifelong hematopoiesis requires maintenance, proliferation, and differentiation of hematopoietic stem cells. Thrombopoietin is a cytokine essential for regulation of hematopoietic stem cells as well as differentiation and maturation of megakaryocytes required for platelet production. Due to these properties, thrombopoietin agonists have been used to treat bone marrow failure syndromes such as aplastic anemia. Through analysis of thrombopoietin gene-deficient mice, my colleagues and I have demonstrated the mechanism of action of thrombopoietin receptor agonists in hematopoietic stem cell maintenance and differentiation. This review focuses on governance of homeostasis in the hematopoietic system by thrombopoietin signaling.
维持终身造血需要造血干细胞的维持、增殖和分化。血小板生成素是一种细胞因子，对于调节造血干细胞以及血小板生成所需的巨核细胞的分化和成熟至关重要。由于这些特性，血小板生成素激动剂已被用于治疗骨髓衰竭综合征，如再生障碍性贫血。通过对血小板生成素基因缺陷小鼠的分析，我和我的同事已经证明了血小板生成素受体激动剂在造血干细胞维持和分化中的作用机制。这篇综述重点关注血小板生成素信号传导对造血系统稳态的调控。
