Narain Priyam, Petković Aleksa, Šušić Marko, Haniffa Salma, Anwar Mariam, Arnoux Marc, Drou Nizar, Antonio-Saldi Giuseppe, Chaudhury Dipesh
Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE.
Department of Biology, New York University Abu Dhabi, Abu Dhabi, UAE.
Transl Psychiatry. 2024 Oct 2;14(1):407. doi: 10.1038/s41398-024-03100-w.
The molecular mechanisms that link stress and biological rhythms still remain unclear. The habenula (Hb) is a key brain region involved in regulating diverse types of emotion-related behaviours while the suprachiasmatic nucleus (SCN) is the body's central clock. To investigate the effects of chronic social stress on transcription patterns, we performed gene expression analysis in the Hb and SCN of stress-naïve and stress-exposed mice. Our analysis revealed a large number of differentially expressed genes and enrichment of synaptic and cell signalling pathways between resilient and stress-naïve mice at zeitgeber 16 (ZT16) in both the Hb and SCN. This transcriptomic signature was nighttime-specific and observed only in stress-resilient mice. In contrast, there were relatively few differences between the stress-susceptible and stress-naïve groups across time points. Our results reinforce the functional link between circadian gene expression patterns and differential responses to stress, thereby highlighting the importance of temporal expression patterns in homoeostatic stress responses.
将压力与生物节律联系起来的分子机制仍不清楚。缰核（Hb）是参与调节多种与情绪相关行为的关键脑区，而视交叉上核（SCN）是人体的中央时钟。为了研究慢性社会压力对转录模式的影响，我们在未经历压力和经历过压力的小鼠的缰核和视交叉上核中进行了基因表达分析。我们的分析揭示了在时间geber 16（ZT16）时，在缰核和视交叉上核中，恢复力强的小鼠与未经历压力的小鼠之间存在大量差异表达基因以及突触和细胞信号通路的富集。这种转录组特征是夜间特异性的，且仅在应激恢复力强的小鼠中观察到。相比之下，在不同时间点，应激易感性小鼠和未经历压力的小鼠之间的差异相对较少。我们的结果强化了昼夜节律基因表达模式与对应激的不同反应之间的功能联系，从而突出了时间表达模式在稳态应激反应中的重要性。
