Nagpal Sunil, Srivastava Sarvesh Kumar
TCS Research, Tata Consultancy Services Ltd, Pune, India.
CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India.
NPJ Biofilms Microbiomes. 2024 Oct 2;10(1):97. doi: 10.1038/s41522-024-00536-2.
Ingestible microdevices represent a breakthrough in non-invasive sampling of the human gastrointestinal (GI) tract. By capturing the native spatiotemporal microbiome and intricate biochemical gradients, these devices allow a non-invasive multi-omic access to the unperturbed host-microbiota crosstalk, immune/nutritional landscapes and gut-organ connections. We present the current progress of GI sampling microdevices towards personalized metabolism and fostering collaboration among clinicians, engineers, and data scientists.
可摄入式微型设备代表了人类胃肠道（GI）非侵入性采样的一项突破。通过捕获天然的时空微生物群和复杂的生化梯度，这些设备能够实现对未受干扰的宿主-微生物群相互作用、免疫/营养状况以及肠道-器官连接进行非侵入性的多组学研究。我们展示了胃肠道采样微型设备在个性化代谢方面的当前进展，以及促进临床医生、工程师和数据科学家之间合作的情况。
