Department of Periodontics, School of Dentistry, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA, 70119, USA.
Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Clin Oral Investig. 2024 Oct 3;28(10):565. doi: 10.1007/s00784-024-05955-1.
To evaluate the efficacy of topically applied hyaluronic acid on wound healing (patient-reported outcomes and clinical healing) after a palatal autogenous gingival graft is harvested.
A systematic search was performed in April 2024 in eleven electronic databases. Two investigators independently screened the references for inclusion. Outcomes of interest included postoperative pain, analgesic consumption, complete epithelialization, and color match, which were synthesized using narrative synthesis.
A total of 535 results were identified and eight articles were included in the systematic review. Hyaluronic acid use on the palatal donor site had a better response to healing and wound size compared to the control sites with no agent applied. Hyaluronic acid demonstrated a positive effect in the form of complete epithelialization, and color match, with improved patient-reported outcomes such as post-operative pain.
Within the limitations of this systematic review, it can be concluded that hyaluronic acid shows a strong potential to improve patient-reported outcomes and clinical wound healing at the graft donor site on the palate. Future studies are required to clarify the optimal concentration, frequency of application, and synergistic effect when HA is combined with other interventions.
Within the limitations of this systematic review, it can be concluded that hyaluronic acid shows a strong potential to improve patient-reported outcomes and clinical wound healing at the graft donor site on the palate. Future studies are required to clarify the optimal concentration, frequency of application, and synergistic effect when HA is combined with other interventions.
评估局部应用透明质酸对腭自体牙龈移植物采集后伤口愈合（患者报告的结果和临床愈合）的疗效。
2024 年 4 月在 11 个电子数据库中进行了系统检索。两名调查员独立筛选纳入的参考文献。感兴趣的结果包括术后疼痛、镇痛药消耗、完全上皮化和颜色匹配，使用叙述性综合法进行综合。
共确定了 535 项结果，其中 8 项文章被纳入系统评价。与未应用任何药物的对照组相比，透明质酸在腭供体部位的使用对愈合和伤口大小有更好的反应。透明质酸在完全上皮化和颜色匹配方面表现出积极的效果，改善了患者报告的术后疼痛等结果。
在本系统评价的限制范围内，可以得出结论，透明质酸显示出在改善患者报告的结果和腭移植物供体部位的临床伤口愈合方面具有很大的潜力。需要进一步的研究来阐明透明质酸与其他干预措施联合应用时的最佳浓度、应用频率和协同作用。
在本系统评价的限制范围内，可以得出结论，透明质酸显示出在改善患者报告的结果和腭移植物供体部位的临床伤口愈合方面具有很大的潜力。需要进一步的研究来阐明透明质酸与其他干预措施联合应用时的最佳浓度、应用频率和协同作用。
