Department of Periodontology, Faculty of Dentistry, Pamukkale University, Kınıklı Campus, 20160, Denizli, Turkey.
Clin Oral Investig. 2023 Jun;27(6):2735-2746. doi: 10.1007/s00784-022-04848-5. Epub 2023 Jan 3.
This study aims to evaluate the effects of topical hyaluronic acid (HA), hypochlorous acid (HOCl), and flurbiprofen on postoperative morbidity of palatal donor sites after free gingival graft (FGG) surgery.
Sixty patients requiring FGG were randomly assigned into four groups: control, HA gel (600 mg/100 g high molecular weight hyaluronic acid), HOCl spray (170-200 ppm, ph7.1), flurbiprofen spray (0.075gr flurbiprofen). Topical agents were applied for 14 days, according to groups. Patients were followed for 28 days. Palatal healing was assessed with the Laundry wound healing index (WHI). Complete epithelization (CE) was evaluated with photographs and HO bubbling. Pain, burning sensation, chewing efficacy, and tissue color match (CM) were evaluated using a visual analog scale (VAS). Postoperative analgesic consumption and delayed bleeding (DB) were also recorded.
HA provided better WHI values on the 7, 14, and 21 days compared to the other groups, respectively (p < 0.05). CE was formed on the 21 day in the HA group but on the 28 day in the other groups. HOCl and flurbiprofen groups were not different from the control group or each other in terms of WHI. HOCl had the lowest VAS scores of all time periods. DB was not observed in any group. Significantly fewer analgesics were taken in the topical agent-applied groups compared to the control group.
HA exhibits a positive impact on the epithelization of palatal wound healing and color matching. HOCl and flurbiprofen provided less pain; however, they might have negative effects on palatal wound healing.
As a result of obtaining free gingival grafts from palatal tissue for mucogingival surgical procedures, secondary wound healing of the donor area occurs. This wound in the palatal region can cause discomfort and pain every time patients use their mouths. The use of HA can reduce postoperative complications by accelerating wound healing and reducing pain. The topical use of flurbiprofen and HOCl can reduce patients' pain.
本研究旨在评估局部透明质酸（HA）、次氯酸（HOCl）和氟比洛芬对游离龈移植（FGG）术后腭部供区术后发病率的影响。
将 60 名需要 FGG 的患者随机分为四组：对照组、HA 凝胶（600mg/100g 高分子量透明质酸）、HOCl 喷雾（170-200ppm，ph7.1）、氟比洛芬喷雾（0.075gr 氟比洛芬）。根据组别，将局部用药应用 14 天。患者随访 28 天。用洗衣伤口愈合指数（WHI）评估腭部愈合情况。用照片和 HO 冒泡评估完全上皮化（CE）。疼痛、烧灼感、咀嚼效能和组织颜色匹配（CM）用视觉模拟量表（VAS）评估。还记录术后镇痛消耗和延迟出血（DB）。
HA 在第 7、14 和 21 天的 WHI 值均优于其他组（p<0.05）。HA 组在第 21 天形成 CE，而其他组在第 28 天形成 CE。HOCl 和氟比洛芬组在 WHI 方面与对照组或彼此之间没有差异。HOCl 在所有时间段的 VAS 评分最低。任何一组均未观察到 DB。与对照组相比，应用局部药物的组需要的镇痛药明显较少。
HA 对腭部伤口愈合和颜色匹配的上皮化有积极影响。HOCl 和氟比洛芬减轻疼痛；然而，它们可能对腭部伤口愈合有负面影响。
由于进行黏膜-牙龈手术，从腭部组织获得游离龈移植物，供区的继发性伤口愈合。腭部区域的这个伤口每次患者使用口腔时都会引起不适和疼痛。使用 HA 可以通过加速伤口愈合和减轻疼痛来减少术后并发症。局部使用氟比洛芬和 HOCl 可以减轻患者的疼痛。
