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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord.

作者信息

Pajer Krisztián, Bellák Tamás, Nógrádi Antal

机构信息

Department of Anatomy, Histology and Embryology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.

出版信息

Neural Regen Res. 2025 Aug 1;20(8):2311-2312. doi: 10.4103/NRR.NRR-D-23-01231. Epub 2024 Sep 6.

DOI:10.4103/NRR.NRR-D-23-01231
PMID:39359084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11759012/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16bc/11759012/641b0d9641d1/NRR-20-2311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16bc/11759012/641b0d9641d1/NRR-20-2311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16bc/11759012/641b0d9641d1/NRR-20-2311-g001.jpg

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本文引用的文献

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Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections.脂质纳米颗粒作为病毒性肺部感染mRNA疫苗的有前景载体
Pharmaceutics. 2023 Apr 3;15(4):1127. doi: 10.3390/pharmaceutics15041127.
2
Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury.脊髓损伤后通过延迟脊髓内递送编码人白细胞介素-10的核苷修饰mRNA恢复运动功能
Research (Wash D C). 2023;6:0056. doi: 10.34133/research.0056. Epub 2023 Mar 9.
3
Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications.
炎症在脊髓损伤后神经损伤和再生中的作用及其治疗意义。
Burns Trauma. 2023 Feb 28;11:tkac054. doi: 10.1093/burnst/tkac054. eCollection 2023.
4
Genetic, Epigenetic, and Post-Transcriptional Basis of Divergent Tissue Regenerative Capacities Among Vertebrates.脊椎动物不同组织再生能力的遗传、表观遗传和转录后基础
Adv Genet (Hoboken). 2021 Jun;2(2). doi: 10.1002/ggn2.10042.
5
RNA-Based Therapies for Neurodegenerative Diseases.基于 RNA 的神经退行性疾病疗法。
Mo Med. 2021 Jul-Aug;118(4):340-345.
6
Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety.LNP-mRNA的非免疫治疗应用:最大化疗效与安全性
Biomedicines. 2021 May 10;9(5):530. doi: 10.3390/biomedicines9050530.
7
Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment.移植的人诱导多能干细胞改善脊髓损伤的预后:损伤微环境的调节。
Sci Rep. 2020 Dec 29;10(1):22414. doi: 10.1038/s41598-020-79846-2.
8
Biology and therapeutic potential of interleukin-10.白细胞介素-10 的生物学特性和治疗潜力
J Exp Med. 2020 Jan 6;217(1). doi: 10.1084/jem.20190418.
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Functional Multipotency of Stem Cells and Recovery Neurobiology of Injured Spinal Cords.干细胞的功能多能性与受损脊髓的神经修复生物学。
Cell Transplant. 2019 Apr;28(4):451-459. doi: 10.1177/0963689719850088. Epub 2019 May 28.
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Neuroectodermal Stem Cells Grafted into the Injured Spinal Cord Induce Both Axonal Regeneration and Morphological Restoration via Multiple Mechanisms.神经外胚层干细胞移植入损伤脊髓后通过多种机制诱导轴突再生和形态学恢复。
J Neurotrauma. 2019 Nov 1;36(21):2977-2990. doi: 10.1089/neu.2018.6332. Epub 2019 Jul 10.