Zhang Xinzhu, Xiong Wu, Kong Guang, Zhen Yushan, Zeng Qiang, Wang Siming, Chen Sheng, Gu Jun, Li Cong, Guo Kaijin
Nanjing Medical University, Nanjing, China.
Department of Orthopedics, The First Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Front Pharmacol. 2022 Aug 5;13:957433. doi: 10.3389/fphar.2022.957433. eCollection 2022.
As a worldwide medical problem, spinal cord injury has no clear and effective treatment to improve its prognosis. Hence, new treatment strategies for spinal cord injury with good therapeutic efficacy have been actively pursued. As a new drug loading system, acetal dextran nanoparticles (SAD) have good biocompatibility and biodegradability. Therefore, we designed spermine-functionalized acetal-dextran (SAD) nanoparticles and encapsulated paclitaxel (PCL) into them. This design can ensure the sustained release of paclitaxel in the injured area for 4 days and promote the extension of nerve processes . In our experiment, we found that paclitaxel-loaded SAD nanoparticles (PCL@SAD) decreased the level of chondroitin sulfate proteoglycan in the rat spinal cord injury model, which reduced the scar repair of the injured site and changed the inhibitory environment after spinal cord injury. This reveals that PCL@SAD can effectively protect the injured spinal cord and ultimately improve the functional recovery of the injured spinal cord. One single injection of PCL@SAD shows better therapeutic effect than that of PCL. This study opens an exciting perspective toward the application of neuroprotective PCL@SAD for the treatment of severe neurological diseases.
作为一个全球性的医学问题，脊髓损伤尚无明确有效的治疗方法来改善其预后。因此，人们一直在积极探索具有良好治疗效果的脊髓损伤新治疗策略。作为一种新型载药系统，缩醛葡聚糖纳米颗粒（SAD）具有良好的生物相容性和生物降解性。因此，我们设计了精胺功能化的缩醛葡聚糖（SAD）纳米颗粒，并将紫杉醇（PCL）包裹于其中。这种设计能够确保紫杉醇在损伤区域持续释放4天，并促进神经突起的延伸。在我们的实验中，我们发现载有紫杉醇的SAD纳米颗粒（PCL@SAD）降低了大鼠脊髓损伤模型中硫酸软骨素蛋白聚糖的水平，减少了损伤部位的瘢痕修复，改变了脊髓损伤后的抑制环境。这表明PCL@SAD能够有效保护受损脊髓，最终改善受损脊髓的功能恢复。单次注射PCL@SAD显示出比PCL更好的治疗效果。本研究为神经保护剂PCL@SAD用于治疗严重神经疾病的应用开辟了一个令人兴奋的前景。
