Tian Fangzhen, Zhang Shu, Wang Miaoyu, Yan Yuxing, Cao Yiyao, Wang Yili, Fan Kelong, Wang Hao, Zhang Jianning, Zhang Xiao-Dong
Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
Department of Neurosurgery and Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Tianjin Medical University General Hospital, Tianjin 300052, China.
ACS Appl Mater Interfaces. 2024 Oct 3. doi: 10.1021/acsami.4c10451.
Silk sutures are common in surgeries, and silk-based textiles are widely used in clinical medicine on account of their great mechanical properties and biodegradability. However, due to the lack of biocatalytic activity, silk sutures show unsatisfactory anti-inflammatory properties and healing speed. To address this constraint, we construct clinical grade bioactive gold cluster-sutures through a heterojunction. The antioxidant activity of bioactive gold cluster-sutures is ∼160 times more than that of clinical sutures. Meanwhile, the suture displays superb reactive oxygen species (ROS) scavenging, superoxide dismutase-like (SOD-like, 5 times more than the silk suture), and catalase-like (CAT-like) activities. The clusters assemble on the surface of silk through hydrogen bonding, leading to a durable catalytic and structural stability for 15 months without decay. Subsequently, the suture significantly accelerates wound healing by exerting excellent anti-inflammatory effects, improving neovascularization and collagen deposition. Clinical grade bioactive gold clusters with high bioactivity, stability, and biocompatibility hold promise for clinical translation and pave the way for other implanted biomaterials from wound healing to intelligent textiles.
丝线缝合线在手术中很常见，基于丝绸的纺织品因其出色的机械性能和生物降解性而在临床医学中被广泛使用。然而，由于缺乏生物催化活性，丝线缝合线的抗炎性能和愈合速度并不理想。为了解决这一限制，我们通过异质结构建了临床级生物活性金簇缝合线。生物活性金簇缝合线的抗氧化活性比临床缝合线高约160倍。同时，该缝合线表现出出色的活性氧（ROS）清除能力、超氧化物歧化酶样（SOD样，比丝线缝合线高5倍）和过氧化氢酶样（CAT样）活性。这些簇通过氢键组装在丝绸表面，实现了15个月的持久催化和结构稳定性且无降解。随后，该缝合线通过发挥出色的抗炎作用、改善新血管形成和胶原蛋白沉积，显著加速了伤口愈合。具有高生物活性、稳定性和生物相容性的临床级生物活性金簇有望实现临床转化，并为从伤口愈合到智能纺织品的其他植入生物材料铺平道路。
