Sourij Harald, Azhar Kehkishan, Aziz Faisal, Kojzar Harald, Sourij Caren, Fasching Peter, Clodi Martin, Ludvik Bernhard, Mader Julia K, Resl Michael, Rega-Kaun Gersina, Ress Claudia, Stechemesser Lars, Stingl Harald, Tripolt Norbert J, Wascher Thomas, Kaser Susanne
Interdisciplinary Metabolic Medicine Trials Unit, Medical University of Graz, Graz, Austria.
Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Diabetes Obes Metab. 2025 Jan;27(1):111-122. doi: 10.1111/dom.15988. Epub 2024 Oct 3.
This study assessed the achievement rates of metabolic risk factor targets and their association with clinical characteristics and comorbidities among individuals with type 2 diabetes (T2D) treated in the primary care in Austria.
A countrywide cross-sectional study, the AUSTRO-PROFIT, was conducted in Austria from 2021 to 2023 on 635 individuals with T2D. Metabolic risk factor targets were defined as the percentage of people achieving low-density lipoprotein cholesterol (LDL-C) <70 mg/dL (or < 55 mg/dL if cardiovascular or microvascular disease was present), glycated haemoglobin (HbA1c) <7% (53 mmol/mol) and blood pressure < 140/90 mmHg.
The mean age of the participants was 65.7 ± 11.2 years; the median duration of T2D was 8 (4-14) years; and 58.7% of the participants were male. The percentages of participants achieving LDL-C, HbA1c, blood pressure and all targets were 44%, 53%, 57% and 13%, respectively. Older age, longer T2D duration, cardiovascular disease and microvascular complications were associated with suboptimal achievement of metabolic risk factor targets.
The AUSTRO-PROFIT study revealed notable variations in metabolic targets achievement with respect to clinical characteristics and comorbidities. These findings underscore the importance of establishing national diabetes registries and implementing multifactorial targeted and individualized interventions to further improve the quality of T2D care in primary care settings in Austria.
本研究评估了奥地利初级医疗中接受治疗的2型糖尿病（T2D）患者代谢危险因素目标的达成率及其与临床特征和合并症的关联。
在奥地利开展了一项全国性横断面研究AUSTRO - PROFIT，研究时间为2021年至2023年，共纳入635例T2D患者。代谢危险因素目标定义为达到低密度脂蛋白胆固醇（LDL - C）<70mg/dL（若存在心血管或微血管疾病则为<55mg/dL）、糖化血红蛋白（HbA1c）<7%（53mmol/mol）以及血压<140/90mmHg的人群百分比。
参与者的平均年龄为65.7±11.2岁；T2D的中位病程为8（4 - 14）年；58.7%的参与者为男性。达到LDL - C、HbA1c、血压以及所有目标的参与者百分比分别为44%、53%、57%和13%。年龄较大、T2D病程较长、心血管疾病和微血管并发症与代谢危险因素目标的未达最佳达成情况相关。
AUSTRO - PROFIT研究揭示了代谢目标达成情况在临床特征和合并症方面存在显著差异。这些发现强调了建立国家糖尿病登记系统以及实施多因素靶向和个体化干预措施对于进一步提高奥地利初级医疗环境中T2D护理质量的重要性。
