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半面痉挛患者的脑结构改变：一项多模态脑结构研究。

Altered Brain Structure in Hemifacial Spasm Patients: A Multimodal Brain Structure Study.

作者信息

Yu Qingyang, Cui Yuanyuan, Dong Shuwen, Ma Yanqing, Xiao Yi, Fan Li, Liu Shiyuan

机构信息

Department of Radiology, Changzheng Hospital, Navy Military Medical University, Shanghai, 200003, People's Republic of China.

Department of Neurosurgery, Changhai Hospital, Navy Military Medical University, Shanghai, 200433, People's Republic of China.

出版信息

Int J Gen Med. 2024 Sep 28;17:4435-4443. doi: 10.2147/IJGM.S464660. eCollection 2024.

DOI:10.2147/IJGM.S464660
PMID:39359615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446207/
Abstract

OBJECTIVE

Hemifacial spasm (HFS) is a clinical neurosurgical disease, which brain structural alterations caused by HFS remain a topic of debate. We evaluated changes in brain microstructure associated with HFS and observed their relevance to clinical characteristics.

METHODS

We enrolled 72 participants. T1-weighted structural and diffusion tensor images were collected from all participants using 3.0T magnetic resonance equipment. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) were used to identify changes in gray matter volume (GMV) and disruptions in white matter (WM) integrity. The severity of the spasms was graded using the Cohn scale.

RESULTS

VBM analysis revealed that the GMV was significantly reduced in the left Thalamus and increased GMV in the right Cerebellum IV-V of the HFS group. TBSS analysis showed that FA in the left superior longitudinal fasciculus (SLF) of the HFS group was significantly increased. GMV in the thalamus showed a negative correlation with disease duration and Cohn grade, while FA in the left SLF had a positive correlation with both the disease duration and Cohn grade.

CONCLUSION

We identified regions with altered GMV in HFS patients. Additionally, we determined that FA in the left SLF might serve as a significant neural indicator of HFS.

摘要

目的

面肌痉挛（HFS）是一种临床神经外科疾病，HFS引起的脑结构改变仍是一个有争议的话题。我们评估了与HFS相关的脑微观结构变化，并观察了它们与临床特征的相关性。

方法

我们招募了72名参与者。使用3.0T磁共振设备从所有参与者收集T1加权结构和扩散张量图像。基于体素的形态学测量（VBM）和基于纤维束的空间统计学（TBSS）用于识别灰质体积（GMV）的变化和白质（WM）完整性的破坏。使用科恩量表对面肌痉挛的严重程度进行分级。

结果

VBM分析显示，HFS组左侧丘脑的GMV显著降低，右侧小脑IV-V的GMV增加。TBSS分析显示，HFS组左侧上纵束（SLF）的FA显著增加。丘脑中的GMV与病程和科恩分级呈负相关，而左侧SLF中的FA与病程和科恩分级均呈正相关。

结论

我们确定了HFS患者中GMV改变的区域。此外，我们确定左侧SLF中的FA可能是HFS的一个重要神经指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e1/11446207/a2c384527f95/IJGM-17-4435-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e1/11446207/defe32bc438f/IJGM-17-4435-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e1/11446207/e84a8d0ee23f/IJGM-17-4435-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e1/11446207/a2c384527f95/IJGM-17-4435-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e1/11446207/defe32bc438f/IJGM-17-4435-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e1/11446207/e84a8d0ee23f/IJGM-17-4435-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e1/11446207/a2c384527f95/IJGM-17-4435-g0003.jpg

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本文引用的文献

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Neuroradiology. 2020 Mar;62(3):369-375. doi: 10.1007/s00234-019-02318-6. Epub 2019 Dec 2.
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Microvascular decompression in patients with hemifacial spasm.微血管减压术治疗面肌痉挛。
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