Ning Yijie, Hu Jie, Li Haifeng, Lu Chuanlong, Zhang Zeyu, Yan Sheng, Shi Peilu, Gao Tingting, Wang Heng, Zhang Ruijing, Dong Honglin
Department of Vascular Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing, China.
Front Cardiovasc Med. 2024 Sep 18;11:1460708. doi: 10.3389/fcvm.2024.1460708. eCollection 2024.
Lower extremity peripheral artery disease (PAD) is a growing global health problem. New methods to diagnose PAD have been explored in recent years. At present, the majority of imaging methods for PAD focus on the macrovascular blood flow, and the exploration of microcirculation and tissue perfusion of PAD remains largely insufficient. In this report, we applied three new imaging technologies, i.e., second near-infrared region (NIR-II, 900-1,880 nm wavelengths) imaging, optical coherence tomography angiography (OCTA), and laser speckle flowgraphy (LSFG), in a PAD patient with a healthy human subject as control. Our results showed that the PAD patient had poorer tissue perfusion than the control without observed adverse effects. Moreover, compared with the first near-infrared region (NIR-I, 700-900 nm wavelengths) imaging results, NIR-II imaging had a higher signal-to-background ratio and resolution than NIR-I imaging and detected microvessels that were not detected by NIR-I imaging. These observations suggested that NIR-II imaging, OCTA, and LSFG are potentially safe and effective methods for diagnosing PAD.
下肢外周动脉疾病（PAD）是一个日益严重的全球性健康问题。近年来人们探索了诊断PAD的新方法。目前，大多数用于PAD的成像方法聚焦于大血管血流，而对PAD微循环和组织灌注的探索仍极为不足。在本报告中，我们将三种新的成像技术，即第二近红外区域（NIR-II，波长900 - 1880 nm）成像、光学相干断层扫描血管造影（OCTA）和激光散斑血流图（LSFG），应用于一名PAD患者，并以一名健康受试者作为对照。我们的结果表明，该PAD患者的组织灌注比对照差，但未观察到不良反应。此外，与第一近红外区域（NIR-I, 700 - 900 nm波长）成像结果相比，NIR-II成像具有比NIR-I成像更高的信噪比和分辨率，且能检测到NIR-I成像未检测到的微血管。这些观察结果表明，NIR-II成像、OCTA和LSFG是诊断PAD潜在安全有效的方法。
