Murphy S, Jeremy J, Pearce B, Dandona P
Neurosci Lett. 1985 Oct 24;61(1-2):61-5. doi: 10.1016/0304-3940(85)90401-x.
Primary cultures of astrocytes and meningeal cells derived from neonatal rat brain synthesize and release thromboxane A2 and prostacyclin, respectively. Exogenously supplied arachidonic acid and the calcium ionophore, A23187, promote the release of eicosanoids; these effects are blocked by indomethacin and the calcium chelator, ethyleneglycoltetraacetic acid. The finding that astrocytes synthesize and release thromboxane A2 is discussed in the light of our recent findings of receptor-linked membrane phospholipid turnover in these cells.
源自新生大鼠脑的星形胶质细胞和脑膜细胞的原代培养物分别合成并释放血栓素A2和前列环素。外源性提供的花生四烯酸和钙离子载体A23187可促进类花生酸的释放；这些作用被吲哚美辛和钙螯合剂乙二醇四乙酸阻断。根据我们最近在这些细胞中发现的受体连接的膜磷脂周转情况，对星形胶质细胞合成并释放血栓素A2这一发现进行了讨论。
