Streiber Anna M, Neitzel Julia, Nguyen Ho Phuong Thuy, Vernooij Meike W, Bos Daniel
Department of Radiology and Nuclear Medicine Erasmus MC Rotterdam the Netherlands.
Department of Epidemiology Erasmus MC Rotterdam the Netherlands.
Alzheimers Dement (Amst). 2024 Oct 1;16(4):e70005. doi: 10.1002/dad2.70005. eCollection 2024 Oct-Dec.
Intracranial arteriosclerosis and cerebral amyloid beta (Aβ) are both involved in the etiology of Alzheimer's disease (AD) dementia, but the direct link between these two pathologies remains elusive.
In 633 participants (mean age 69 years, 51% women) from the population-based Rotterdam Study, we quantified cerebral Aβ accumulation on amyloid positron emission tomography (PET). We assessed calcification of the intracranial internal carotid (ICAC) and vertebrobasilar arteries (VBAC) as proxies of arteriosclerosis on non-enhanced computed tomography (CT). Using logistic and linear regression, we studied the relationship of presence, burden, and type of calcification with the presence and burden of Aβ.
We found no associations of ICAC [odds ratio (OR): 0.85, 95% confidence interval (CI): 0.43, 1.72] or VBAC [OR: 0.59, CI: 0.26, 1.24] with cerebral Aβ. The results did not vary across ICAC subtypes.
Intracranial arteriosclerosis was not associated with cerebral Aβ, underscoring their independence in the etiology of AD dementia.
Comprehensive assessment of intracranial arteriosclerosis (e.g., including subtypes).Intracranial arteriosclerosis in different arteries and cerebral Aβ are not related.Arteriosclerosis and Aβ likely influence Alzheimer's disease dementia independently.
颅内动脉硬化和脑淀粉样β蛋白（Aβ）均与阿尔茨海默病（AD）痴呆的病因有关，但这两种病理之间的直接联系仍不明确。
在基于人群的鹿特丹研究的633名参与者（平均年龄69岁，51%为女性）中，我们通过淀粉样正电子发射断层扫描（PET）对脑Aβ积累进行了量化。我们在非增强计算机断层扫描（CT）上评估颅内颈内动脉（ICAC）和椎基底动脉（VBAC）的钙化情况，以此作为动脉硬化的指标。使用逻辑回归和线性回归，我们研究了钙化的存在、负担和类型与Aβ的存在和负担之间的关系。
我们发现ICAC[比值比（OR）：0.85，95%置信区间（CI）：0.43，1.72]或VBAC[OR：0.59，CI：0.26，1.24]与脑Aβ之间无关联。结果在ICAC各亚型之间没有差异。
颅内动脉硬化与脑Aβ无关，这突出了它们在AD痴呆病因中的独立性。
对颅内动脉硬化进行全面评估（例如，包括亚型）。不同动脉的颅内动脉硬化与脑Aβ无关。动脉硬化和Aβ可能独立影响阿尔茨海默病痴呆。
