Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Neurobiol Aging. 2021 Sep;105:16-24. doi: 10.1016/j.neurobiolaging.2021.04.005. Epub 2021 Apr 22.
Intracranial arteriosclerosis has been increasingly recognized as a risk factor for cognitive impairment and even dementia. A possible mechanism linking intracranial arteriosclerosis to cognitive impairment and dementia involves structural brain changes including cerebral small vessel disease (CSVD). To assess whether intracranial carotid artery calcification (ICAC) and vertebrobasilar artery calcification (VBAC), as proxies for intracranial arteriosclerosis, are related to CSVD. Within the population-based Rotterdam Study, between 2003 and 2006 a computed tomography (CT)-based measurement of ICAC and VBAC and at least one magnetic resonance imaging (MRI) measurement of structural brain changes were performed from 2005 onwards in 1,489 participants. To estimate the burden of calcification independent of age, we computed age-adjusted percentile curves for ICAC and VBAC separately, based on the calcification volumes. Using the longitudinal MRI data, we assessed whether a larger calcification burden accelerates structural brain changes using appropriate statistical models for repeated outcome measures. A larger burden of ICAC and VBAC was associated with an increase of CSVD markers accelerating over time. A larger burden of ICAC and VBAC was not significantly (p > 0.05) associated with accelerated brain atrophy. Arteriosclerosis is related to accelerating structural brain changes over time.
颅内动脉硬化已被越来越多地认为是认知障碍甚至痴呆的危险因素。一种将颅内动脉硬化与认知障碍和痴呆联系起来的可能机制涉及包括脑小血管病（CSVD）在内的结构性脑变化。为了评估颅内颈动脉硬化（ICAC）和椎基底动脉钙化（VBAC）作为颅内动脉硬化的替代指标是否与 CSVD 有关。在基于人群的鹿特丹研究中，2003 年至 2006 年期间，在 1489 名参与者中进行了基于计算机断层扫描（CT）的 ICAC 和 VBAC 测量，以及至少一项磁共振成像（MRI）结构脑变化测量，从 2005 年开始。为了独立于年龄估计钙化负担，我们根据钙化体积分别计算了 ICAC 和 VBAC 的年龄调整百分位数曲线。使用纵向 MRI 数据，我们使用适当的重复测量结果统计模型评估了更大的钙化负担是否会加速结构性脑变化。更大的 ICAC 和 VBAC 负担与 CSVD 标志物的增加有关，随着时间的推移而加速。更大的 ICAC 和 VBAC 负担与加速脑萎缩无显著相关性（p > 0.05）。动脉硬化与随着时间的推移结构脑变化的加速有关。
