O'Brien Helen, Murray John, Orfali Nina, Fahy Ruairi J
Division of Respiratory Medicine, St James Hospital, Dublin, Ireland.
These authors contributed equally.
Breathe (Sheff). 2024 Oct 1;20(3):240043. doi: 10.1183/20734735.0043-2024. eCollection 2024 Oct.
Bone marrow transplantation, now often known as haematopoietic stem cell transplantation (HSCT), is a complex choreographed procedure used to treat both acquired and inherited disorders of the bone marrow. It has proven invaluable as therapy for haematological and immunological disorders, and more recently in the treatment of metabolic and enzyme disorders. As the number of performed transplants grows annually, and with patients enjoying improved survival, a knowledge of both early and late complications of HSCT is essential for respiratory trainees and physicians in practice. This article highlights the spectrum of respiratory complications, both infectious and non-infectious, the timeline of their likely occurrence, and the approaches used for diagnosis and treatment, keeping in mind that more than one entity may occur simultaneously. As respiratory issues are often a leading cause of short- and long-term morbidity, consideration of a combined haematology/respiratory clinic may prove useful in this patient population.
骨髓移植，现在通常称为造血干细胞移植（HSCT），是一种用于治疗获得性和遗传性骨髓疾病的复杂精细的程序。事实证明，它作为治疗血液学和免疫性疾病的疗法非常宝贵，最近还用于治疗代谢和酶紊乱疾病。随着每年进行的移植手术数量不断增加，且患者生存率提高，了解HSCT的早期和晚期并发症对于呼吸科实习医生和执业医师来说至关重要。本文重点介绍了呼吸并发症的范围，包括感染性和非感染性并发症、它们可能发生的时间线以及用于诊断和治疗的方法，同时要记住可能会同时出现多种情况。由于呼吸问题通常是短期和长期发病的主要原因，因此考虑设立血液学/呼吸科联合门诊可能对这类患者群体有用。
