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从病原体到毒素:桑布·纳特·德博士在理解霍乱方面的革命性工作。

From Pathogen to Toxin: The Revolutionary Work of Dr. Sambhu Nath De in Understanding Cholera.

作者信息

Handa Alisha, Choudhari Sonali G, Gaidhane Abhay

机构信息

Department of Community Medicine, School of Epidemiology and Public Health, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Sep 1;16(9):e68414. doi: 10.7759/cureus.68414. eCollection 2024 Sep.

DOI:10.7759/cureus.68414
PMID:39360053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11445544/
Abstract

In the history of medical science and public health in India, the groundbreaking research on cholera toxin by Dr. Sambhu Nath De presents a pivotal moment. This review article dives into Dr. De's influential contributions to the understanding of cholera pathogenesis, his discovery of the cholera toxin, and its implications for the treatment and prevention of diseases. By defining the process via which vibrio cholera causes severe diarrhea and dehydration, Dr. De worked toward paving the way for the development of effective rehydration therapies and preventive strategies that have helped save innumerable lives all over the world. This article also reviews the more significant impact of Dr. De's findings in the field of public health and its shaping and use of modern approaches to infectious control. This article aims to honor the enduring legacy and contributions to public health reform by Dr. De.

摘要

在印度医学科学和公共卫生的历史上,桑布·纳特·德博士对霍乱毒素的开创性研究是一个关键的时刻。这篇综述文章深入探讨了德博士对理解霍乱发病机制的有影响力的贡献、他对霍乱毒素的发现及其对疾病治疗和预防的影响。通过确定霍乱弧菌导致严重腹泻和脱水的过程,德博士努力为开发有效的补液疗法和预防策略铺平道路,这些疗法和策略在全世界帮助挽救了无数生命。本文还回顾了德博士的发现在公共卫生领域更重大的影响,以及其对现代传染病控制方法的塑造和应用。本文旨在纪念德博士对公共卫生改革的持久遗产和贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2f/11445544/30a9db1c93d8/cureus-0016-00000068414-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2f/11445544/30a9db1c93d8/cureus-0016-00000068414-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab2f/11445544/30a9db1c93d8/cureus-0016-00000068414-i01.jpg

相似文献

1
From Pathogen to Toxin: The Revolutionary Work of Dr. Sambhu Nath De in Understanding Cholera.从病原体到毒素:桑布·纳特·德博士在理解霍乱方面的革命性工作。
Cureus. 2024 Sep 1;16(9):e68414. doi: 10.7759/cureus.68414. eCollection 2024 Sep.
2
From endotoxin to exotoxin: De's rich legacy to cholera.从内毒素到外毒素:De 丰富的遗产与霍乱。
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A De in the life of cholera.霍乱弧菌的生活史。
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On the discovery of the nature of cholera toxin in India.
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Dr Sambhu Nath De: unsung hero.桑布·纳特·德博士:无名英雄。
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History of development of oral rehydration therapy.口服补液疗法的发展历程。
Indian J Public Health. 1994 Apr-Jun;38(2):39-43.
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Treatment of cholera-like diarrhoea with oral rehydration.口服补液治疗霍乱样腹泻
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In Commemoration of Dr. Mostafa Pourtaghva Shahrestani, a Pioneer in Infectious Disease Research.纪念穆斯塔法·普尔塔格瓦·沙赫雷斯塔尼博士,传染病研究先驱。
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本文引用的文献

1
From Bacterial Poisons to Toxins: The Early Works of Pasteurians.从细菌毒素到毒素:巴斯德学派的早期作品。
Toxins (Basel). 2022 Nov 3;14(11):759. doi: 10.3390/toxins14110759.
2
Tribute: Dr. Sambhu Nath De: one of the greatest Indian scientists.
Indian J Pathol Microbiol. 2015 Jan-Mar;58(1):134-6.
3
A De in the life of cholera.霍乱弧菌的生活史。
Indian J Med Res. 2011 Feb;133(2):146-52.
4
Dr Sambhu Nath De: unsung hero.桑布·纳特·德博士:无名英雄。
Indian J Med Res. 2011 Feb;133(2):127.
5
From endotoxin to exotoxin: De's rich legacy to cholera.从内毒素到外毒素:De 丰富的遗产与霍乱。
Bull World Health Organ. 2010 Mar;88(3):237-40. doi: 10.2471/BLT.09.072504.
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An experimental study of the mechanism of action of Vibriod cholerae on the intestinal mucous membrane.霍乱弧菌对肠黏膜作用机制的实验研究
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Treatment of cholera--tradition and authority versus science, reason, and humanity.
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