National Institute of Cholera and Enteric Diseases, P-33 - CIT Scheme XM, Beliaghata, Kolkata, 700 010, India.
Bull World Health Organ. 2010 Mar;88(3):237-40. doi: 10.2471/BLT.09.072504.
Between 1951 and 1959, Sambhu Nath De made crucial discoveries on the pathogenesis of cholera that changed the course of our understanding of the disease. The discovery that cholera is caused by a potent exotoxin (cholera enterotoxin) affecting intestinal permeability, the demonstration that bacteria-free culture filtrates of Vibrio cholerae were enterotoxic, and the development of a reproducible animal model for the disease are considered milestones in the history of the fight against cholera. In this commentary, a classic article by De & Chatterje published in 1953 and its public health and research impact are highlighted.
1951 年至 1959 年间，Sambhu Nath De 对霍乱的发病机制做出了重大发现，改变了我们对这种疾病的认识。他发现霍乱是由一种强效外毒素（霍乱肠毒素）引起的，会影响肠道通透性，证明霍乱弧菌的无细菌培养滤液具有肠毒性，并且开发了一种可重现的动物霍乱模型，这些都被认为是对抗霍乱斗争史上的里程碑。在这篇评论中，突出介绍了 De 和 Chatterje 于 1953 年发表的一篇经典文章及其对公共卫生和研究的影响。
