Department of Radiology, Dalian Women and Children's Medical Group, Dalian, Liaoning, PR China.
Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, PR China.
Acta Radiol. 2024 Nov;65(11):1440-1446. doi: 10.1177/02841851241277339. Epub 2024 Oct 3.
Lymphovascular space invasion (LVSI) is a strong and independent risk factor that increases the probability of endometrial carcinoma (EC) recurrence and reduces the survival rate of patients.
To investigate the value of amide proton transfer weighted (APTw) and mDixon-Quant techniques in evaluating EC lymphovascular space invasion (LVSI).
Data of 50 EC patients (18 LVSI+ and 32 LVSI-) confirmed by surgery and pathology were retrospectively analyzed. Preoperative magnetic resonance imaging (MRI) scans included APTw and mDixon-Quant imaging. APT, transverse relaxation rate (R2*), and fat fraction (FF) plots were obtained by postprocessing. The APT, R2*, and FF values of the two groups of cases were measured by two observers.
The agreement between the two observers was good. The mean APT, R2*, and FF values of LVSI+ EC were 2.947% ± 0.399%, 20.605 /s (range = 18.525-27.953), and 2.234% ± 1.047%, respectively, while the parameters of LVSI- EC were 2.628% ± 0.307%, 18.968 /s (range = 16.225-20.544), and 2.103% ± 1.070%, respectively. The APT and R2* values of LVSI+ EC were higher than those of LVSI- EC (< 0.05). There was no significant difference in FF value between the two groups. The AUC values of APT, R2*, and APT + R2* for LVSI were 0.751, 0.713, and 0.781, respectively (all > 0.05). APT value was moderately correlated with R2* value (r = 0.528, < 0.001) and weakly correlated with FF value (= 0.312, = 0.027).
APTw and mDixon-Quant techniques could evaluate the LVSI status of EC, and their combined application could improve diagnostic efficiency.
脉管侵犯（LVSI）是子宫内膜癌（EC）复发的一个强有力的独立危险因素，降低了患者的生存率。
探讨酰胺质子转移加权（APTw）和 mDixon-Quant 技术评估子宫内膜癌脉管侵犯（LVSI）的价值。
回顾性分析 50 例经手术和病理证实的 EC 患者（18 例 LVSI+和 32 例 LVSI-）的数据。术前磁共振成像（MRI）扫描包括 APTw 和 mDixon-Quant 成像。通过后处理获得 APT、横向弛豫率（R2*）和脂肪分数（FF）图。两名观察者测量两组病例的 APT、R2*和 FF 值。
两名观察者的一致性良好。LVSI+EC 的平均 APT、R2和 FF 值分别为 2.947%±0.399%、20.605/s（范围=18.525-27.953）和 2.234%±1.047%，而 LVSI-EC 的参数分别为 2.628%±0.307%、18.968/s（范围=16.225-20.544）和 2.103%±1.070%。LVSI+EC 的 APT 和 R2值高于 LVSI-EC（<0.05）。两组间 FF 值无显著差异。APT、R2和 APT+R2* 对 LVSI 的 AUC 值分别为 0.751、0.713 和 0.781（均>0.05）。APT 值与 R2值中度相关（r=0.528，<0.001），与 FF 值弱相关（r=0.312，p=0.027）。
APTw 和 mDixon-Quant 技术可评估 EC 的 LVSI 状态，联合应用可提高诊断效率。
