mDIXON-Quant 用于区分慢性肾脏病患者的肾损伤程度。
mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease.
机构信息
First Affiliated Hospital, Dalian Medical University, Dalian, China.
Clinical and Technical Support, Philips Healthcare, Beijing, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jul 21;14:1187042. doi: 10.3389/fendo.2023.1187042. eCollection 2023.
BACKGROUND
Chronic kidney disease (CKD) is a complex syndrome with high morbidity and slow progression. Early stages of CKD are asymptomatic and lack of awareness at this stage allows CKD to progress through to advanced stages. Early detection of CKD is critical for the early intervention and prognosis improvement.
PURPOSE
To assess the capability of mDIXON-Quant imaging to detect early CKD and evaluate the degree of renal damage in patients with CKD.
STUDY TYPE
Retrospective.
POPULATION
35 patients with CKD: 18 cases were classifified as the mild renal damage group (group A) and 17 cases were classifified as the moderate to severe renal damage group (group B). 22 healthy volunteers (group C).
FIELD STRENGTH/SEQUENCE: A 3.0 T/TWI, TWI and mDIXON-Quant sequences.
ASSESSMENT
Transverse relaxation rate (R2*) values and fat fraction (FF) values derived from the mDIXON-Quant were calculated and compared among the three groups.
STATISTICAL TESTS
The intra-class correlation (ICC) test; Chi-square test or Fisher's exact test; Shapiro-Wilk test; Kruskal Wallis test with adjustments for multiplicity (Bonferroni test); Area under the receiver operating characteristic (ROC) curve (AUC). The significance threshold was set at P < 0.05.
RESULTS
Cortex FF values and cortex R2* values were significantly different among the three groups (P=0.028, <0.001), while medulla R2* values and medulla FF values were not (P=0.110, 0.139). Cortex FF values of group B was significantly higher than that of group A (Bonferroni adjusted P = 0.027). Cortex R2* values of group A and group B were both significantly higher than that of group C (Bonferroni adjusted P = 0.012, 0.001). The AUC of cortex FF values in distinguishing group A and group B was 0.766. The diagnostic efficiency of cortex R2* values in distinguishing group A vs. group C and group B vs. group C were 0.788 and 0.829.
CONCLUSION
The mDIXON-Quant imaging had a potential clinical value in early diagnosis of CKD and assessing the degree of renal damage in CKD patients.
背景
慢性肾脏病（CKD）是一种发病率高、进展缓慢的复杂综合征。CKD 的早期阶段没有症状，并且在此阶段缺乏意识，这使得 CKD 进展到晚期。早期发现 CKD 对于早期干预和改善预后至关重要。
目的
评估 mDIXON-Quant 成像检测早期 CKD 的能力，并评估 CKD 患者的肾脏损伤程度。
研究类型
回顾性。
人群
35 名 CKD 患者：18 例分为轻度肾损伤组（A 组），17 例分为中重度肾损伤组（B 组）。22 名健康志愿者（C 组）。
磁场强度/序列：3.0T/T1WI、T2WI 和 mDIXON-Quant 序列。
评估
计算并比较三组之间来自 mDIXON-Quant 的横向弛豫率（R2*）值和脂肪分数（FF）值。
统计检验
组内相关（ICC）检验；卡方检验或 Fisher 精确检验；Shapiro-Wilk 检验；Kruskal-Wallis 检验（多重调整：Bonferroni 检验）；接收者操作特征（ROC）曲线下面积（AUC）。显著性阈值设为 P < 0.05。
结果
三组间皮质 FF 值和皮质 R2值差异有统计学意义（P=0.028，<0.001），而髓质 R2值和髓质 FF 值差异无统计学意义（P=0.110，0.139）。B 组皮质 FF 值明显高于 A 组（Bonferroni 调整后 P=0.027）。A 组和 B 组皮质 R2值均明显高于 C 组（Bonferroni 调整后 P=0.012，0.001）。皮质 FF 值鉴别 A 组和 B 组的 AUC 为 0.766。皮质 R2值鉴别 A 组与 C 组、B 组与 C 组的诊断效率分别为 0.788 和 0.829。
结论
mDIXON-Quant 成像在 CKD 的早期诊断和评估 CKD 患者的肾脏损伤程度方面具有潜在的临床价值。
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