Zhang Ning-Ning, Mychinko Mikhail, Gao Shu-Yang, Yu Linxiuzi, Shen Zhi-Li, Wang Liang, Peng Fei, Wei Zhonglin, Wang Zizhun, Zhang Wei, Zhu Shoujun, Yang Yang, Sun Tianmeng, Liz-Marzán Luis M, Bals Sara, Liu Kun
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China.
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun 130012, China.
Nano Lett. 2024 Oct 3. doi: 10.1021/acs.nanolett.4c03782.
To achieve chiral amplification, life uses small chiral molecules as building blocks to construct hierarchical chiral architectures that can realize advanced physiological functions. Inspired by the chiral amplification strategy of nature, we herein demonstrate that the chiral assembly of chiral gold nanorods (GNRs) leads to enhanced optical asymmetry factors (-factors), up to 0.24. The assembly of chiral GNRs, dictated by structural self-matching, leads to -factors with over 100-fold higher values than those of individual chiral GNRs, as confirmed by numerical simulations. Moreover, the efficient optical asymmetry of chiral GNR assemblies enables their application as highly sensitive sensors of adenosine triphosphate (ATP detection limit of 1.0 μM), with selectivity against adenosine diphosphate and adenosine monophosphate.
为了实现手性放大，生命利用小型手性分子作为构建单元来构建能够实现高级生理功能的分级手性结构。受自然手性放大策略的启发，我们在此证明手性金纳米棒（GNRs）的手性组装导致光学不对称因子（g-因子）增强，高达0.24。由结构自匹配决定的手性GNRs组装导致g-因子的值比单个手性GNRs的值高100倍以上，数值模拟证实了这一点。此外，手性GNR组装体的高效光学不对称性使其能够用作三磷酸腺苷的高灵敏度传感器（ATP检测限为1.0 μM），对二磷酸腺苷和一磷酸腺苷具有选择性。
