Gomaa Islam, Aleid Ghadah, El-Moslamy Shahira H, AlShammari Anoud, Al-Marshedy Sumayyah, Alshammary Freah, Gharkan Jouza, Abdel-Hameed Reda, Kamoun Elbadawy A
Nanotechnology Research Centre (NTRC), The British University in Egypt (BUE), Suez Desert Road, El-Sherouk City, Cairo, 11837, Egypt.
Basic Science Departments, Preparatory Year, University of Ha'il, 1560, Hail, Kingdom of Saudi Arabia.
Discov Nano. 2024 Oct 3;19(1):164. doi: 10.1186/s11671-024-04085-7.
Antibiotic resistance is currently becoming a more serious threat to global health, especially in severe nosocomial infections treatment by multidrug-resistant bacteria. This research provides a new way of synergizing green-synthesis for zinc oxide quantum dots (ZnO-QDs with hexagonal crystals) that are 7 nm in diameter and zero-valent Ag cubic crystals that are 67 nm in size embedded with nitazoxanide substrate (NAZ). Instrumental characterization like SEM, TEM, EDAX, and FT-IR and comprehensive antimicrobial studies were conducted to study the incorporation behavior of composites based on Ag NPs/ZnO QDs/NAZ. This combination has not been hitherto addressed anywhere else in the published literature, as well as commercial viability. In this context, we have precisely tuned nanoparticle to nitazoxanide ratio for designing the formulation demonstrating potent activity against MDR infections. By employing nitazoxanide as a scaffold and careful decoration thereof antimicrobial potency has been unlocked overriding conventional therapies. In addition, Ag NPs/ZnO-QDs/nitazoxanide (G6) formula exhibited a therapeutic efficacy span of 96.15 ± 1.68% to 99.57 ± 0.20% against MDR human infections post 48 h incubation; a breakthrough in therapeutic efficacy levels has been achieved by our method. Accordingly, ZnO QDs/Ag NPs/NAZ composite offered potential multidrug resistant human pathogens as a new trend of revolutionizing antimicrobial treatment.
抗生素耐药性目前正成为对全球健康更严重的威胁，尤其是在多重耐药菌所致严重医院感染的治疗方面。本研究提供了一种新的绿色合成协同方法，用于制备直径为7纳米的六方晶体氧化锌量子点（ZnO-QDs）以及尺寸为67纳米的零价银立方晶体，并嵌入硝唑尼特底物（NAZ）。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、能量散射X射线谱（EDAX）和傅里叶变换红外光谱（FT-IR）等仪器表征以及全面的抗菌研究，来研究基于银纳米颗粒/ZnO量子点/NAZ复合材料的掺入行为。这种组合在已发表的文献中尚未在其他任何地方提及，也未涉及商业可行性。在此背景下，我们精确调整了纳米颗粒与硝唑尼特的比例，以设计出对多重耐药感染具有强效活性的制剂。通过将硝唑尼特用作支架并对其进行精心修饰，已释放出超越传统疗法的抗菌效力。此外，银纳米颗粒/ZnO-QDs/硝唑尼特（G6）配方在孵育48小时后对多重耐药人类感染的治疗效果范围为96.15±1.68%至99.57±0.20%；我们的方法在治疗效果水平上取得了突破。因此，ZnO量子点/银纳米颗粒/NAZ复合材料为潜在的多重耐药人类病原体提供了一种革新抗菌治疗的新趋势。
