J Drugs Dermatol. 2024 Oct 1;23(10):889-893. doi: 10.36849/JDD.2024.8321.
Granuloma annulare is a benign, non-infectious cutaneous granulomatous disease. Its pathogenesis is not completely elucidated but has recently been thought to involve immunologic and cytokine receptor signaling dysregulation. This includes the involvement of both Th1 and Th2 pathways as well as Th17 and Th22 axes and the Janus kinase/signal transducers and activators of the transcription (JAK-STAT) pathway. First-line treatment is typically intralesional or topical corticosteroids, however, these therapies do not always provide consistent, long-term efficacy for all patients. The successful use of therapies that target the specific inflammatory and immunologic mechanisms that underlie the pathogenesis of GA has been described. Here we describe a case of long-standing GA treated with tapinarof cream 1% applied once daily for 30 days. To our knowledge, this treatment has not yet been adequately described in the literature. J Drugs Dermatol. 2024;23(10):889-893. doi:10.36849/JDD.8321.
环状肉芽肿是一种良性、非传染性皮肤肉芽肿性疾病。其发病机制尚未完全阐明，但最近认为涉及免疫和细胞因子受体信号失调。这包括 Th1 和 Th2 途径以及 Th17 和 Th22 轴以及 Janus 激酶/信号转导和转录激活物 (JAK-STAT) 途径的参与。一线治疗通常是局部或局部皮质类固醇，但这些治疗并非对所有患者都始终有效。针对 GA 发病机制所涉及的特定炎症和免疫机制的治疗方法已被成功应用。在这里，我们描述了一例长期存在的 GA 患者，每天应用 1%他卡西醇乳膏治疗 30 天。据我们所知，这种治疗方法尚未在文献中充分描述。J 皮肤病药物杂志。2024;23(10):889-893.
