Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, 430023, China.
Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, 430023, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.
Virology. 2024 Dec;600:110251. doi: 10.1016/j.virol.2024.110251. Epub 2024 Sep 26.
Cationic liposome-embedded squalene (CLS) is a promising adjuvant that enhances antigen stability and mobility and improves immune response. This study compares the efficacy of a CLS-adjuvant porcine circovirus type 2 (PCV2) vaccine (CSV) with a conventional vaccine against PCV2. The CSV vaccine showed superior stability and was effective against PCV2-induced growth decline. It significantly increased serum immunoglobulin and cytokine levels, reduced serum PCV2 DNA, shortened the duration of viremia, and provided robust protection. CSV outperformed conventional vaccines, highlighting its potential for innovative vaccine development.
阳离子脂质体包埋角鲨烯（CLS）是一种有前途的佐剂，可增强抗原的稳定性和流动性，改善免疫反应。本研究比较了 CLS 佐剂猪圆环病毒 2 型（PCV2）疫苗（CSV）与传统 PCV2 疫苗的功效。CSV 疫苗表现出更好的稳定性，对 PCV2 诱导的生长下降有效。它显著增加了血清免疫球蛋白和细胞因子水平，降低了血清 PCV2 DNA，缩短了病毒血症持续时间，并提供了强大的保护。CSV 优于传统疫苗，突出了其在创新疫苗开发方面的潜力。
