Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China.
Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland.
Int J Pharm. 2024 Dec 5;666:124787. doi: 10.1016/j.ijpharm.2024.124787. Epub 2024 Oct 2.
Nanoparticles (NPs) have gained significant attention in recent years due to their potential applications in pharmaceutical formulations, drug delivery systems, and various biomedical fields. The versatility of colloidal NPs, including their ability to be tailored with various components and synthesis methods, enables drug delivery systems to achieve controlled release patterns, improved solubility, and increased bioavailability. The review discusses various types of NPs, such as nanocrystals, lipid-based NPs, and inorganic NPs (i.e., gold, silver, magnetic NPs), each offering unique advantages for drug delivery. Despite the promising potential of NPs, challenges such as physical instability and the need for surface stabilization remain. Strategies to overcome these challenges include the use of surfactants, polymers, and cyclodextrins (CDs). This review highlights the role of CDs in stabilizing colloidal NPs and enhancing drug solubility. The combination of CDs with NPs presents a synergistic approach that enhances drug delivery and broadens the range of biomedical applications. Additionally, the potential of CDs to enhance the stability and therapeutic efficacy of colloidal NPs, making them promising candidates for advanced drug delivery systems, is comprehensively reviewed.
纳米粒子（NPs）由于其在药物制剂、药物传递系统和各种生物医学领域的潜在应用而受到广泛关注。胶体 NPs 的多功能性，包括其能够用各种成分和合成方法进行定制的能力，使药物传递系统能够实现控制释放模式、提高溶解度和增加生物利用度。本综述讨论了各种类型的 NPs，如纳米晶体、基于脂质的 NPs 和无机 NPs（即金、银、磁性 NPs），每种 NPs 都为药物传递提供了独特的优势。尽管 NPs 具有很有前景的潜力，但仍存在物理不稳定性和需要表面稳定化等挑战。克服这些挑战的策略包括使用表面活性剂、聚合物和环糊精（CDs）。本综述强调了 CDs 在稳定胶体 NPs 和提高药物溶解度方面的作用。CDs 与 NPs 的结合呈现出协同作用，增强了药物传递，并拓宽了生物医学应用的范围。此外，还全面综述了 CDs 提高胶体 NPs 的稳定性和治疗效果的潜力，使它们成为先进药物传递系统的有前途的候选物。
