Gao Yikun, Sun Le, Qiao Chu, Liu Yuqing, Wang Yang, Feng Rui, Zhang Hong, Zhang Youxi
School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China.
School of Pharmacy, China Medical University, Shenyang 110122, China.
Carbohydr Polym. 2025 Mar 15;352:123174. doi: 10.1016/j.carbpol.2024.123174. Epub 2024 Dec 24.
Cyclodextrins (CDs) are cyclic polysaccharides characterized by their unique hollow structure, making them highly effective carriers for pharmaceutical agents. CD-based delivery systems are extensively utilized to enhance drug stability, increase solubility, improve oral bioavailability, and facilitate controlled release and targeted delivery. This review initially provides a concise overview of nano drug delivery systems, followed by a detailed introduction of the structural features and benefits of CDs. It further summarizes the applications of CD-based delivery systems and offers insights for the rational design of drug delivery systems. In this review, CD-based delivery systems are categorized into several types, such as covalently modified CD derivatives, non-modified CD inclusion complexes, poly-cyclodextrins and others. The application of CD-based systems for the delivery of genetic therapeutic agents and co-delivery of gene and drug is also presented. Finally, this review discusses potential challenges and opportunities that may arise in the future. With the development of nanotechnology and optimization of preparation process, CD-based drug delivery systems will provide a more effective, precise and safe approach to drug therapy.
环糊精（CDs）是一类环状多糖，其独特的中空结构使其成为药物的高效载体。基于环糊精的递送系统被广泛用于提高药物稳定性、增加溶解度、改善口服生物利用度以及促进控释和靶向递送。本综述首先简要概述了纳米药物递送系统，随后详细介绍了环糊精的结构特征和优势。它进一步总结了基于环糊精的递送系统的应用，并为药物递送系统的合理设计提供了见解。在本综述中，基于环糊精的递送系统被分为几种类型，如共价修饰的环糊精衍生物、未修饰的环糊精包合物、聚环糊精等。还介绍了基于环糊精的系统在基因治疗药物递送以及基因与药物共递送方面的应用。最后，本综述讨论了未来可能出现的潜在挑战和机遇。随着纳米技术的发展和制备工艺的优化，基于环糊精的药物递送系统将为药物治疗提供一种更有效、精确和安全的方法。
