Rys Ryan N, Calcinotto Arianna
Institute of Oncology Research (IOR), 6500 Bellinzona, Switzerland; Università della Svizzera Italiana, Faculty of Biomedical Sciences, 6900 Lugano, Switzerland.
Institute of Oncology Research (IOR), 6500 Bellinzona, Switzerland; Università della Svizzera Italiana, Faculty of Biomedical Sciences, 6900 Lugano, Switzerland.
Trends Cell Biol. 2025 May;35(5):399-411. doi: 10.1016/j.tcb.2024.09.001. Epub 2024 Oct 2.
Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body of literature has shown that tumor-associated neutrophils (TANs) acquire a prolonged lifespan. This review discusses recent work surrounding the mechanisms by which neutrophils can persist in the tumor microenvironment (TME). It also highlights different scenarios for therapeutic targeting of protumorigenic neutrophils, supporting the idea that, in tumors, inhibition of neutrophil recruitment is not sufficient because these cells can persist and remain hidden from current interventions. Hence, the elimination of long-lived neutrophils should be pursued to increase the efficacy of standard therapy.
中性粒细胞最近在癌症研究中受到了越来越多的关注，因为它们在癌症的各个阶段都发挥着作用。到目前为止，中性粒细胞被认为半衰期较短。然而，越来越多的文献表明，肿瘤相关中性粒细胞（TANs）的寿命会延长。这篇综述讨论了围绕中性粒细胞在肿瘤微环境（TME）中持续存在的机制的最新研究。它还强调了针对促肿瘤中性粒细胞进行治疗靶向的不同情况，支持了这样一种观点，即在肿瘤中，抑制中性粒细胞募集是不够的，因为这些细胞可以持续存在并且能够躲避当前的干预措施。因此，应该致力于清除长寿中性粒细胞，以提高标准治疗的疗效。
