CRISPR/Cas：一种用于设计和改良油料作物的强大工具。

CRISPR/Cas: a powerful tool for designing and improving oil crops.

作者信息

Li Lijie, Zhang Dangquan, Zhang Zhiyong, Zhang Baohong

机构信息

Henan Collaborative Innovation Center of Modern Biological Breeding, Henan Key Laboratory for Molecular Ecology and Germplasm Innovation of Cotton and Wheat, and Xinxiang Key Laboratory of Crop Root Biology and Green Efficient Production, School of Life Sciences, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China; Department of Biology, East Carolina University, Greenville, NC 27858, USA.

Henan Province Engineering Research Center for Forest Biomass Value-Added Products, College of Forestry, Henan Agricultural University, Zhengzhou, Henan 450002, China.

出版信息

Trends Biotechnol. 2025 Apr;43(4):773-789. doi: 10.1016/j.tibtech.2024.09.007. Epub 2024 Oct 3.

DOI:10.1016/j.tibtech.2024.09.007

PMID:39362812

Abstract

Improving oil yield and quality is a major goal for crop breeding, and CRISPR/Cas-mediated genome editing has opened a new era for designing oil crops with enhanced yield and quality. CRISPR/Cas technology can not only increase oil production but also enhance oil quality, including enhancing pharmaceutical and health components, improving oil nutrients, and removing allergic and toxic components. As new molecular targets for oil biosynthesis are discovered and the CRISPR/Cas system is further improved, CRISPR/Cas will become a better molecular tool for designing new oil crops with higher oil production, enhanced nutrients, and improved health components. 'CRISPRized' oil crops will have broad applications both in industry (e.g., as biofuels) and in daily human life.

摘要

提高油产量和质量是作物育种的主要目标，而CRISPR/Cas介导的基因组编辑为设计高产优质的油料作物开创了一个新时代。CRISPR/Cas技术不仅可以提高油脂产量，还能提升油脂品质，包括增强药用和健康成分、改善油脂营养以及去除过敏和有毒成分。随着油生物合成新分子靶点的发现以及CRISPR/Cas系统的进一步改进，CRISPR/Cas将成为设计高产、营养丰富且健康成分优良的新型油料作物的更好分子工具。“CRISPR化”的油料作物在工业（如用作生物燃料）和人类日常生活中都将有广泛应用。