双相情感障碍与神经退行性疾病的前瞻性研究。

Prospective study of bipolar disorder and neurodegenerative diseases.

作者信息

Xu Xinming, Li Yaqi, Lu Hanyu, Wang Han, Guo Yi, Dregan Alexandru, Sun Liang, Shen Yun, Geng Tingting, Gao Xiang

机构信息

Department of Nutrition and Food Hygiene, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, 200030, China.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

出版信息

NPJ Parkinsons Dis. 2024 Oct 3;10(1):184. doi: 10.1038/s41531-024-00794-z.

DOI:10.1038/s41531-024-00794-z

PMID:39362870

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11450157/

Abstract

Bipolar disorder (BD) is linked to an increased risk of neurodegenerative diseases such as dementia and Parkinson disease (PD), yet several uncertainties still remain and the extent to which the associations could be explained by BD-related medications (antipsychotics, lithium, and antiepileptics) was unknown. This study included 501,233 UK Biobank participants (mean [standard deviation] age, 56.5 [8.10] years; 54.4% women), free of dementia and PD at baseline. After a median 13.8 year follow-up, 9422 cases of dementia and 3457 PD cases were identified. Participants with BD had a significantly higher risk of dementia (adjusted hazard ratio [HR] 2.52, 95% CI 2.00-3.19) and PD (adjusted HR 2.88, 95% CI 2.03-4.08). Findings suggest that up to two-thirds of the association of neurodegenerative diseases with BD may be mediated by BD-related medications. Further research is needed to confirm these findings and explore the underlying mechanisms.

摘要

双相情感障碍（BD）与痴呆症和帕金森病（PD）等神经退行性疾病的风险增加有关，但仍存在一些不确定性，而且BD相关药物（抗精神病药物、锂盐和抗癫痫药物）在多大程度上可以解释这种关联尚不清楚。本研究纳入了501233名英国生物银行参与者（平均[标准差]年龄为56.5[8.10]岁；54.4%为女性），这些参与者在基线时无痴呆症和PD。经过中位数为13.8年的随访，确定了9422例痴呆症病例和3457例PD病例。患有BD的参与者患痴呆症（调整后的风险比[HR]为2.52，95%置信区间为2.00-3.19）和PD（调整后的HR为2.88，95%置信区间为2.03-4.08）的风险显著更高。研究结果表明，神经退行性疾病与BD之间的关联中，高达三分之二可能是由BD相关药物介导的。需要进一步的研究来证实这些发现并探索潜在机制。