预防性使用葡萄糖凝胶预防低血糖的新生儿。
Prophylactic dextrose gel use in newborns at risk for hypoglycemia.
机构信息
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
University of Arkansas for Medical Sciences College of Medicine, Little Rock, AR, USA.
出版信息
J Perinatol. 2024 Nov;44(11):1640-1646. doi: 10.1038/s41372-024-02133-9. Epub 2024 Oct 3.
OBJECTIVE
To assess the impact of prophylactic dextrose gel on short-term outcomes in infants at risk for hypoglycemia.
METHODS
Retrospective, single-center, observational study of neonates at risk for hypoglycemia -infants of diabetic mothers, large and small for gestational age infants, born between January 2015 and May 2023. Infants were categorized into two groups for analysis. 1. Pre- dextrose gel (01/2015 to 04/2018, n = 788) and 2. Dextrose gel (01/2019 to 05/2023, n = 1495). Infant demographic data and outcome variables were compared between the two groups.
RESULTS
2283 infants were eligible. Prophylactic dextrose gel use was associated with decreased admission rates to NICU secondary to hypoglycemia (2.7% vs. 6.5%), reduced incidence of hypoglycemia (32% vs. 43.3%), and higher exclusive breastmilk use at discharge (47% vs. 37.3%).
CONCLUSION
The use of prophylactic dextrose gel in certain high-risk newborns was associated with improved patient outcomes.
目的
评估预防性葡聚糖凝胶对低血糖风险婴儿短期结局的影响。
方法
对 2015 年 1 月至 2023 年 5 月期间患有糖尿病母亲的婴儿、大于胎龄儿和小于胎龄儿等低血糖风险新生儿进行回顾性、单中心、观察性研究。将婴儿分为两组进行分析。1. 葡聚糖凝胶前（2015 年 1 月至 2018 年 4 月，n=788）和 2. 葡聚糖凝胶（2019 年 1 月至 2023 年 5 月，n=1495）。比较两组婴儿的人口统计学数据和结局变量。
结果
共有 2283 名婴儿符合条件。预防性葡聚糖凝胶的使用与因低血糖而入住新生儿重症监护病房的比例降低（2.7% vs. 6.5%）、低血糖发生率降低（32% vs. 43.3%）以及出院时纯母乳喂养率升高（47% vs. 37.3%）相关。
结论
在某些高危新生儿中使用预防性葡聚糖凝胶可改善患者结局。
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