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θ相位进动支持人类自然主义体验的记忆形成与提取。

Theta phase precession supports memory formation and retrieval of naturalistic experience in humans.

作者信息

Zheng Jie, Yebra Mar, Schjetnan Andrea G P, Patel Kramay, Katz Chaim N, Kyzar Michael, Mosher Clayton P, Kalia Suneil K, Chung Jeffrey M, Reed Chrystal M, Valiante Taufik A, Mamelak Adam N, Kreiman Gabriel, Rutishauser Ueli

机构信息

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Department of Neurological Surgery, University of California, Davis, Davis, CA, USA.

出版信息

Nat Hum Behav. 2024 Dec;8(12):2423-2436. doi: 10.1038/s41562-024-01983-9. Epub 2024 Oct 3.

DOI:10.1038/s41562-024-01983-9
PMID:39363119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11659172/
Abstract

Associating different aspects of experience with discrete events is critical for human memory. A potential mechanism for linking memory components is phase precession, during which neurons fire progressively earlier in time relative to theta oscillations. However, no direct link between phase precession and memory has been established. Here we recorded single-neuron activity and local field potentials in the human medial temporal lobe while participants (n = 22) encoded and retrieved memories of movie clips. Bouts of theta and phase precession occurred following cognitive boundaries during movie watching and following stimulus onsets during memory retrieval. Phase precession was dynamic, with different neurons exhibiting precession in different task periods. Phase precession strength provided information about memory encoding and retrieval success that was complementary with firing rates. These data provide direct neural evidence for a functional role of phase precession in human episodic memory.

摘要

将不同的经验方面与离散事件相关联对人类记忆至关重要。连接记忆成分的一种潜在机制是相位进动，在此期间神经元相对于theta振荡在时间上逐渐提前放电。然而，相位进动与记忆之间尚未建立直接联系。在这里，我们记录了人类内侧颞叶的单神经元活动和局部场电位，同时参与者（n = 22）对电影片段进行编码和回忆。在观看电影期间的认知边界之后以及记忆检索期间的刺激开始之后出现了theta和相位进动。相位进动是动态的，不同的神经元在不同的任务阶段表现出进动。相位进动强度提供了有关记忆编码和检索成功的信息，这些信息与放电率互补。这些数据为相位进动在人类情景记忆中的功能作用提供了直接的神经证据。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/625c/11659172/25b29db50e2b/41562_2024_1983_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/625c/11659172/a5f0999734f6/41562_2024_1983_Fig8_ESM.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/625c/11659172/1d4f8875c001/41562_2024_1983_Fig12_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/625c/11659172/5ef99f7116cf/41562_2024_1983_Fig13_ESM.jpg
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