Huynh Phu M, Wang Fenfen, An Yu A
Department of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
J Mol Cell Biol. 2025 Jan 30;16(8). doi: 10.1093/jmcb/mjae039.
Obesity per se is rapidly emerging all over the planet and further accounts for many other life-threatening conditions, such as diabetes, cardiovascular diseases, and cancers. Decreased oxygen supply or increased relative oxygen consumption in the adipose tissue results in adipose tissue hypoxia, which is a hallmark of obesity. This review aims to provide an up-to-date overview of the hypoxia signaling in the adipose tissue. First, we summarize literature evidence to demonstrate that hypoxia is regularly observed during adipose tissue remodeling in humans and rodent models with obesity. Next, we discuss how hypoxia-inducible factors (HIFs) are regulated and how adipose tissues behave in response to hypoxia. Then, the differential roles of adipose HIF-1α and HIF-2α in adipose tissue biology and obesity pathology are highlighted. Finally, the review emphasizes the importance of modulating adipose hypoxia as a therapeutic avenue to assist adipose tissues in functionally adapting to hypoxic conditions, ultimately promoting adipose health and improving outcomes due to obesity.
肥胖本身正在全球迅速蔓延，并且还引发许多其他危及生命的疾病，如糖尿病、心血管疾病和癌症。脂肪组织中氧气供应减少或相对氧消耗增加会导致脂肪组织缺氧，这是肥胖的一个标志。本综述旨在提供脂肪组织中缺氧信号的最新概述。首先，我们总结文献证据，以证明在人类和肥胖啮齿动物模型的脂肪组织重塑过程中经常观察到缺氧。接下来，我们讨论缺氧诱导因子（HIFs）是如何被调节的，以及脂肪组织对缺氧的反应。然后，重点介绍脂肪组织中HIF-1α和HIF-2α在脂肪组织生物学和肥胖病理学中的不同作用。最后，本综述强调调节脂肪组织缺氧作为一种治疗途径的重要性，以帮助脂肪组织在功能上适应缺氧条件，最终促进脂肪健康并改善肥胖导致的后果。
