Brunner Stefan, Krewitz Christina, Winter Raphaela, von Falkenhausen Aenne S, Kern Anna, Brunner Dorothee, Sinner Moritz F
Department of Medicine I, LMU University Hospital, LMU Munich, Ziemssenstr. 5, 80336 Munich, Germany.
German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Ziemssenstr. 5, 80336 Munich, Germany.
Eur Heart J. 2024 Dec 7;45(46):4938-4949. doi: 10.1093/eurheartj/ehae695.
Acute excessive alcohol intake may cause the holiday heart syndrome, characterized by cardiac arrhythmias including atrial fibrillation. Since underlying data are scarce, the study aimed to prospectively investigate the temporal course of occurring cardiac arrhythmias following binge drinking in young adults.
A total of 202 volunteers planning acute alcohol consumption with expected peak breath alcohol concentrations (BACs) of ≥1.2 g/kg were enrolled. The study comprised 48 h electrocardiogram monitoring covering baseline (Hour 0), 'drinking period' (Hours 1-5), 'recovery period' (Hours 6-19), and two control periods corresponding to 24 h after the 'drinking' and 'recovery periods', respectively. Acute alcohol intake was monitored by BAC measurements during the 'drinking period'. Electrocardiograms were analysed for mean heart rate, atrial tachycardia, premature atrial complexes, premature ventricular complexes (PVCs), and heart rate variability measures.
Data revealed an increase in heart rate and an excess of atrial tachycardias with increasing alcohol intake. Heart rate variability analysis indicated an autonomic modulation with sympathetic activation during alcohol consumption and the subsequent 'recovery period', followed by parasympathetic predominance thereafter. Premature atrial complexes occurred significantly more frequently in the 'control periods', whereas PVCs were more frequent in the 'drinking period'. Ten participants experienced notable arrhythmic episodes, including atrial fibrillation and ventricular tachycardias, primarily during the 'recovery period'.
The study demonstrates the impact of binge drinking on heart rate alterations and increased atrial tachycardias during 'drinking period', and the occurrence of clinically relevant arrhythmias during the 'recovery period', emphasizing the holiday heart syndrome as a health concern.
急性过量饮酒可能导致假日心脏综合征，其特征为包括心房颤动在内的心律失常。由于相关基础数据匮乏，本研究旨在前瞻性调查年轻成年人暴饮后心律失常的发生时间进程。
共招募了202名计划急性饮酒且预期呼气酒精浓度（BAC）峰值≥1.2 g/kg的志愿者。该研究包括48小时心电图监测，涵盖基线（第0小时）、“饮酒期”（第1 - 5小时）、“恢复期”（第6 - 19小时），以及分别对应“饮酒期”和“恢复期”后24小时的两个对照期。在“饮酒期”通过测量BAC来监测急性酒精摄入情况。对心电图进行分析，以获取平均心率、房性心动过速、房性早搏、室性早搏（PVC）以及心率变异性指标。
数据显示，随着酒精摄入量增加，心率上升且房性心动过速增多。心率变异性分析表明，在饮酒期间及随后的“恢复期”存在交感神经激活的自主调节，之后副交感神经占主导。房性早搏在“对照期”出现的频率显著更高，而PVC在“饮酒期”更为频繁。10名参与者经历了明显的心律失常发作，包括心房颤动和室性心动过速，主要发生在“恢复期”。
该研究表明暴饮对“饮酒期”心率改变和房性心动过速增加有影响，以及在“恢复期”出现临床相关心律失常，强调假日心脏综合征是一个健康问题。
