Myers W F, Wisseman C L, Fiset P, Oaks E V, Smith J F
Infect Immun. 1979 Dec;26(3):976-83. doi: 10.1128/iai.26.3.976-983.1979.
We investigated the recent claim that the vole agent, a rickettsia-like microorganism isolated from wild voles by Baker in 1946, is actually a strain of Rochalimaea quintana, the etiological agent of trench fever. The two organisms were compared on the basis of percent guanine-plus-cytosine content, genome size, deoxyribonucleic acid-deoxyribonucleic acid hybridization, polypeptide composition, and serological relationships. Although the two organisms do have identical or nearly identical deoxyribonucleic acid base ratios and show some serological cross-reactions, they differ substantially by all of the other criteria employed. They are clearly different, although possibly related, organisms. It remains to be determined whether they can be regarded as two species of the same genus. On the other hand, an Old World strain and a New World strain of R. quintana were indistinguishable from one another by the same criteria.
我们对最近的一项说法进行了调查，该说法称1946年贝克从野生田鼠中分离出的类立克次氏体微生物——田鼠病原体，实际上是战壕热的病原体五日热罗卡利马氏体的一个菌株。我们根据鸟嘌呤加胞嘧啶含量百分比、基因组大小、脱氧核糖核酸-脱氧核糖核酸杂交、多肽组成以及血清学关系对这两种微生物进行了比较。尽管这两种微生物确实具有相同或几乎相同的脱氧核糖核酸碱基比率，并且显示出一些血清学交叉反应，但根据所采用的所有其他标准，它们存在很大差异。它们显然是不同的生物体，尽管可能存在关联。它们是否可被视为同一属的两个物种仍有待确定。另一方面，通过相同的标准，旧世界的五日热罗卡利马氏体菌株和新世界的菌株无法区分。
