Laboratory of Microbiology, Shangcheng District Center for Disease Control and Prevention, Hangzhou, China.
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Epidemiol Infect. 2024 Oct 4;152:e117. doi: 10.1017/S0950268824001341.
is an emerging foodborne enteropathogen associated with infectious diarrhoea in humans. In February 2023, an outbreak of acute gastroenteric cases was reported in a junior high school located in Hangzhou, Zhejiang province, China. Twenty-two investigated patients presented diarrhoea (22/22, 100%), abdominal pain (21/22, 95.5%), nausea (6/22, 27.3%), and vomiting (3/22, 13.6%). strains were successfully isolated from anal swabs collected from six patients. Each isolate was classified as sequence type ST2686, harboured -β gene, and carried both -I and -II subtypes, being serotyped as EAOg32:EAHg4 serotype. A comprehensive whole-genome phylogenetic analysis revealed that the six isolates formed a distinct cluster, separate from other strains. These isolates exhibited minimal genetic variation, differing from one another by 0 to 1 single nucleotide polymorphism, suggesting a common origin from a single clone. To the best of our knowledge, this represented the first reported outbreak of gastroenteritis attributed to outside of Japan on a global scale.
是一种新兴的食源性肠道病原体，与人类感染性腹泻有关。2023 年 2 月，中国浙江省杭州市一所初中发生了一起急性肠胃炎暴发疫情。对 22 名调查患者的症状进行分析，发现 22 名患者均出现腹泻（22/22，100%）、腹痛（21/22，95.5%）、恶心（6/22，27.3%）和呕吐（3/22，13.6%）。从 6 名患者的肛拭子中成功分离出 菌株。每个分离株均被归类为 ST2686 序列型，携带-β基因，并同时携带-I 和 -II 亚型，血清型为 EAOg32：EAHg4 血清型。全面的全基因组系统发育分析显示，这 6 个分离株形成了一个独特的聚类，与其他菌株分开。这些分离株的遗传变异很小，彼此之间仅相差 0 到 1 个单核苷酸多态性，表明它们源自一个单一的克隆。据我们所知，这是首次在全球范围内报道的由 引起的肠胃炎暴发疫情，而非日本。
