Plash Sonu, Soni Deepti, Mukhopadhyay Sramana, Yadav Moorat Singh, Kaushal Devashish, Mehra Ketan
Department of Urology, All India Institute of Medical Sciences (AIIMS) Bhopal, Saket Nagar, Habib Ganj, Bhopal, Madhya Pradesh 462026, India.
Department of Pathology, All India Institute of Medical Sciences (AIIMS) Bhopal, Saket Nagar, Habib Ganj, Bhopal, Madhya Pradesh 462026, India.
J Kidney Cancer VHL. 2024 Oct 1;11(4):10-14. doi: 10.15586/jkcvhl.v11i4.335. eCollection 2024.
Germ cell tumor (GCT) is a neoplasm typically found in childhood, commonly originating from the testis or ovary. While there have been reported cases of GCT occurring in various extragonadal sites, primary intrarenal GCT is exceptionally rare. We present a case of 37-year-old male who presented with right upper abdomen pain. Imaging revealed a sizable mass within the right kidney. The patient underwent surgical resection of the renal mass during which there was perirenal infiltration into the duodenum and dense desmoplastic reaction all around. Subsequent histopathology confirmed the diagnosis of primary intrarenal nonseminomatous germ cell tumor (NSGCT). The patient underwent four cycles of adjuvant bleomycin, etoposide, and cisplatin (BEP) chemotherapy; at 6 months of follow-up, he is fine. The objective of this case report is to underscore the importance of considering NSGCT as a potential rare differential diagnosis in cases of renal neoplasms and further plan for the management.
生殖细胞肿瘤（GCT）是一种通常在儿童期发现的肿瘤，常见于睾丸或卵巢。虽然已有报道称GCT发生于各种性腺外部位，但原发性肾内GCT极为罕见。我们报告一例37岁男性，因右上腹疼痛就诊。影像学检查显示右肾内有一个较大肿块。患者接受了肾肿块手术切除，术中发现肾周浸润至十二指肠，周围有致密的促纤维组织增生反应。随后的组织病理学确诊为原发性肾内非精原细胞瘤性生殖细胞肿瘤（NSGCT）。患者接受了四个周期的博来霉素、依托泊苷和顺铂（BEP）辅助化疗；随访6个月时，他情况良好。本病例报告的目的是强调在肾肿瘤病例中考虑NSGCT作为潜在罕见鉴别诊断的重要性，并进一步制定治疗方案。
