Shen Ruyue, Chan Leo Ka Yu, Yip Amber Cheuk Wing, Chan Poemen P
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Jet King-Shing Ho Glaucoma Treatment and Research Centre, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Front Med (Lausanne). 2024 Sep 19;11:1428850. doi: 10.3389/fmed.2024.1428850. eCollection 2024.
Glaucoma is a leading cause of irreversible blindness worldwide, with its pathophysiology remaining inadequately understood. Among the various proposed theories, the vascular theory, suggesting a crucial role of retinal vasculature deterioration in glaucoma onset and progression, has gained significant attention. Traditional imaging techniques, such as fundus fluorescein angiography, are limited by their invasive nature, time consumption, and qualitative output, which restrict their efficacy in detailed retinal vessel examination. Optical coherence tomography angiography (OCTA) emerges as a revolutionary imaging modality, offering non-invasive, detailed visualization of the retinal and optic nerve head microvasculature, thereby marking a significant advancement in glaucoma diagnostics and management. Since its introduction, OCTA has been extensively utilized for retinal vasculature imaging, underscoring its potential to enhance our understanding of glaucoma's pathophysiology, improving diagnosis, and monitoring disease progression. This review aims to summarize the current knowledge regarding the role of OCTA in glaucoma, particularly its potential applications in diagnosing, monitoring, and understanding the pathophysiology of the disease. Parameters pertinent to glaucoma will be elucidated to illustrate the utility of OCTA as a tool to guide glaucoma management.
青光眼是全球不可逆性失明的主要原因之一，其病理生理学仍未得到充分理解。在各种提出的理论中，血管学说认为视网膜血管病变在青光眼的发生和发展中起关键作用，该学说已引起了广泛关注。传统的成像技术，如眼底荧光血管造影，因其具有侵入性、耗时且输出结果定性等局限性，限制了它们在详细检查视网膜血管方面的功效。光学相干断层扫描血管造影（OCTA）作为一种革命性的成像方式应运而生，它能够对视网膜和视神经乳头微血管进行非侵入性的详细可视化，从而在青光眼的诊断和管理方面取得了重大进展。自问世以来，OCTA已被广泛用于视网膜血管成像，凸显了其在增进我们对青光眼病理生理学的理解、改善诊断以及监测疾病进展方面的潜力。本综述旨在总结当前关于OCTA在青光眼中作用的知识，特别是其在诊断、监测和理解该疾病病理生理学方面的潜在应用。将阐明与青光眼相关的参数，以说明OCTA作为指导青光眼管理工具的实用性。
