Uehara Kazuya, Sunada Yosuke, Kondo Sumio, Matsuo Shinji
Global Innovation Center, Nissin Foods Holdings Co., Ltd., 2100 Tobukimachi, Hachioji-shi, Tokyo 192-0001, Japan.
Fukushima Healthcare Center, Medical Corporation Kensho-kai, 2-12-16 Tamagawa, Fukushima, Osaka-shi, Osaka 553-0004, Japan.
Biosci Microbiota Food Health. 2024;43(4):381-390. doi: 10.12938/bmfh.2023-086. Epub 2024 Aug 6.
This research aimed to examine the effect of daily intake of food containing strain T21 (T21) on skin conditions and inflammation-related markers in healthy adults who experience itching because of dry skin and have an atopic predisposition. A randomized, double-blind, placebo-controlled parallel-group study was conducted on 44 subjects aged 20 to 64 years. Subjects were randomly assigned to receive a T21-containing food or placebo daily for 8 weeks. The hydration of stratum corneum, trans-epidermal water loss, skin brightness (), skin redness (), and quality of life (QOL) scores were evaluated. Moreover, SCCA2, Th1/Th2, peripheral blood eosinophil count, TGF-β1, TARC, total IgE, and LDH were measured as inflammation-related markers. The results showed that, compared with the placebo, food containing T21 reduced trans-epidermal water loss in the neck and increased neck skin brightness () after 8 weeks of consumption. Furthermore, a stratified analysis in subjects with a history of atopy showed improvements in neck skin redness () and skin-related QOL. No significant improvement in inflammation-related markers was observed. Intake of food containing T21 for 8 weeks in healthy adult with atopic predisposition was suggested to improve skin barrier function in the neck and brightness in the neck skin. Furthermore, the results also suggested that it had the effect of improving rough skin and reducing discomfort due to dryness in healthy adults with a history of atopy.
本研究旨在探讨每日摄入含菌株T21（T21）的食物对因皮肤干燥而瘙痒且有特应性倾向的健康成年人皮肤状况及炎症相关标志物的影响。对44名年龄在20至64岁的受试者进行了一项随机、双盲、安慰剂对照的平行组研究。受试者被随机分配，每天接受含T21的食物或安慰剂，为期8周。评估角质层水合作用、经表皮水分流失、皮肤亮度（）、皮肤发红（）和生活质量（QOL）评分。此外，测量SCCA2、Th1/Th2、外周血嗜酸性粒细胞计数、TGF-β1、TARC、总IgE和LDH作为炎症相关标志物。结果显示，与安慰剂相比，食用含T21的食物8周后，颈部的经表皮水分流失减少，颈部皮肤亮度（）增加。此外，对有特应性病史的受试者进行分层分析显示，颈部皮肤发红（）和皮肤相关生活质量有所改善。未观察到炎症相关标志物有显著改善。建议有特应性倾向的健康成年人摄入含T21的食物8周，以改善颈部皮肤屏障功能和颈部皮肤亮度。此外，结果还表明，它对有特应性病史的健康成年人有改善皮肤粗糙和减轻干燥不适的作用。
