Department of Microbiology, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Laboratory Animal Research Center, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Nutrients. 2020 Mar 14;12(3):763. doi: 10.3390/nu12030763.
Some lactic acid bacteria (LAB) are known to improve atopic dermatitis (AD) through the regulation and stimulation of the host immune system. In this study, we found that ingestion of yogurt containing 11/19-B1 strain ( 11/19-B1) daily for 8 weeks significantly improved the severity scoring of atopic dermatitis (SCORAD) system score from 38.8 ± 14.4 to 24.2 ± 12.0 in children suffering from AD. We tried to identify which LAB species among the five species contained in the test yogurt contributed to the improvement in AD pathology using an AD mouse model induced by repeated application of 1-fluoro-2, 4-dinitrobenzene (DNFB). AD-like skin lesions on the dorsal skin and ear were most improved by 11/19-B1 intake among the five LAB species. In addition, analysis of CD4+ T cell subsets in Peyer's patches (PPs) and cervical lymph nodes (CLNs) indicated that the intake of 11/19-B1 generally suppressed all subsets related to inflammation, i.e., Th1, Th2 and Th17, instead of activating the suppressive system, Treg, in the AD mouse model. Histological observations showed ingestion of 11/19-B1 significantly suppressed severe inflammatory findings, such as inflammatory cell filtration, epidermal erosion and eosinophil infiltration. These results suggest that the immunomodulatory effects of 11/19-B1 contribute to improvements in AD pathology.
一些乳酸菌（LAB）被认为通过调节和刺激宿主免疫系统来改善特应性皮炎（AD）。在这项研究中，我们发现每天摄入含有 11/19-B1 株（11/19-B1）的酸奶 8 周，可显著改善 AD 患者的特应性皮炎严重程度评分（SCORAD）系统评分，从 38.8±14.4 降至 24.2±12.0。我们试图使用 1-氟-2,4-二硝基苯（DNFB）反复应用诱导的 AD 小鼠模型来鉴定测试酸奶中包含的五种 LAB 物种中的哪一种对 AD 病理学的改善有贡献。在五种 LAB 物种中，11/19-B1 的摄入最能改善 AD 样皮肤病变的背部皮肤和耳朵。此外，对派尔氏斑（PPs）和颈淋巴结（CLNs）中 CD4+T 细胞亚群的分析表明，11/19-B1 的摄入通常抑制所有与炎症相关的亚群，即 Th1、Th2 和 Th17，而不是在 AD 小鼠模型中激活抑制系统 Treg。组织学观察表明，11/19-B1 的摄入可显著抑制严重的炎症发现，如炎症细胞滤过、表皮侵蚀和嗜酸性粒细胞浸润。这些结果表明，11/19-B1 的免疫调节作用有助于改善 AD 病理学。
