扩展炎症参数（EIP）作为系统性硬化症炎症的标志物

Extended Inflammation Parameters (EIP) as Markers of Inflammation in Systemic Sclerosis.

作者信息

Kowalska-Kępczyńska Anna, Mleczko Mateusz, Komajda Kamila, Michalska-Jakubus Małgorzata, Krasowska Dorota, Korpysz Maciej

机构信息

Department of Biochemical Diagnostics Chair of Laboratory Diagnostics Medical University of Lublin, al. Solidarności 8, Lublin 20-081, Poland.

Department of Dermatology Venereology and Pediatric Dermatology Medical University of Lublin, ul. Staszica 11, Lublin 20-081, Poland.

出版信息

Int J Inflam. 2024 Sep 26;2024:3786206. doi: 10.1155/2024/3786206. eCollection 2024.

DOI:10.1155/2024/3786206

PMID:39364215

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11449563/

Abstract

BACKGROUND

Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation, progressive vasculopathy, and fibrosis of skin and internal organs. The aim of the study was to evaluate extended inflammatory parameters (EIP) in patients with SSc in comparison to the control group of healthy subjects.

METHODS

A total of 28 patients with SSc and 29 healthy controls (HCs) were included in the study. The following EIP parameters were analyzed: neutrophil reactive intensity (NEUT-RI), neutrophil granularity intensity (NEUT-GI), antibody-synthesizing lymphocytes (AS-LYMP), and reactive lymphocytes (RE-LYMP).

RESULTS

Patients with SSc showed significantly higher values of parameters determining neutrophil reactivity and neutrophil granularity when compared to HCs (respectively, 49.16 FI vs. 44.33 FI, < 0.001, and 152.01 SI vs. 147.51 SI, < 0.001). Moreover, patients with SSc had higher absolute numbers of RE-LYMP than HCs (0.69 × 10/l vs. 0.04 × 10/l, < 0.001). Importantly, significant correlations between the RE-LYMP and either IL-6 ( = 0.447, < 0.001) or ESR ( = 0.532, < 0.001) were found among patients with SSc.

CONCLUSIONS

Changes in NEUT-RI, NEUT-GI, and RE-LYMP levels positively correlate with inflammation in SSc and, thus, could potentially be used as an additional reliable inflammatory biomarker to assess inflammation in this disease.

摘要

背景

系统性硬化症（SSc）是一种自身免疫性疾病，其特征为炎症、进行性血管病变以及皮肤和内脏器官纤维化。本研究的目的是评估系统性硬化症患者与健康对照人群相比的扩展炎症参数（EIP）。

方法

本研究共纳入28例系统性硬化症患者和29例健康对照者（HCs）。分析了以下EIP参数：中性粒细胞反应强度（NEUT-RI）、中性粒细胞颗粒度强度（NEUT-GI）、抗体合成淋巴细胞（AS-LYMP）和反应性淋巴细胞（RE-LYMP）。

结果

与健康对照者相比，系统性硬化症患者的中性粒细胞反应性和中性粒细胞颗粒度参数值显著更高（分别为49.16 FI对44.33 FI，<0.001；152.01 SI对147.51 SI，<0.001）。此外，系统性硬化症患者的RE-LYMP绝对数高于健康对照者（0.69×10⁹/L对0.04×10⁹/L，<0.001）。重要的是，在系统性硬化症患者中发现RE-LYMP与IL-6（r = 0.447，<0.001）或ESR（r = 0.532，<0.001）之间存在显著相关性。