Kuber Rajesh, Durgi Eshan Chetan, Jhala Neeha A, Jainani Urvashi R, Mane Rahul, Shah Rohan N, Shukla Amanya
Radiology, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, IND.
Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, IND.
Cureus. 2024 Sep 3;16(9):e68553. doi: 10.7759/cureus.68553. eCollection 2024 Sep.
Background Hypertensive disorders of pregnancy, especially its dreaded complication preeclampsia, remain a major cause of morbidity and mortality for both the mother and the fetus. Existing tools for the prediction of preeclampsia remain inadequate in their sensitivity and specificity. Hence, there is an urgent need for a reliable, economically feasible, and objective marker for its diagnosis/early prediction. In this regard, shear wave elastography has shown great promise. Shear wave elastography is a novel method to quantify tissue stiffness, which is objective and has significantly lower inter-observer variability. Objectives We aim to quantify the tissue elasticity using point shear wave elastography (pSWE) in the placentas of diagnosed cases of preeclampsia and to compare them with the placentas of healthy controls in order to evaluate if there is a significant statistical difference between the two. Materials and methods This comparative study was conducted at the Department of Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, India, from August 2022 to July 2024. The study included 60 participants, divided into two groups: 30 patients with preeclampsia and 30 healthy pregnancies. Placental stiffness was measured using a Samsung HS70A ultrasound machine (Samsung Electronics Pvt. Ltd., Seoul, South Korea), and pSWE was performed with a curvilinear probe. Data was analyzed using IBM SPSS Statistics for Windows, Version 21 (Released 2012; IBM Corp., Armonk, New York, United States), and the significance of differences between the two groups was assessed using an independent t-test with a p-value of <0.05, considered statistically significant. Results The mean placental stiffness, measured in kilopascals (kPa), was significantly higher in the preeclampsia group (11.71 ± 1.52 kPa) in comparison to the healthy group (3.36 ± 0.66 kPa) (p = 0.001). Patients suffering from preeclampsia were found to have significantly higher levels of placental stiffness. Conclusion Early diagnosis remains key to managing preeclampsia so that adequate monitoring and treatment could be provided to the patients. Our study showed that there is a significant statistical difference in the placental stiffness in patients with preeclampsia in comparison to a healthy placenta. Hence, shear wave elastography can be used as a supplementary tool to aid in the diagnosis/prediction of preeclampsia.
妊娠期高血压疾病，尤其是其可怕的并发症子痫前期，仍然是孕产妇和胎儿发病和死亡的主要原因。现有的子痫前期预测工具在敏感性和特异性方面仍然不足。因此，迫切需要一种可靠、经济可行且客观的诊断/早期预测标志物。在这方面，剪切波弹性成像已显示出巨大的前景。剪切波弹性成像是一种量化组织硬度的新方法，它客观且观察者间变异性显著更低。
我们旨在使用点剪切波弹性成像（pSWE）量化子痫前期确诊病例胎盘的组织弹性，并将其与健康对照的胎盘进行比较，以评估两者之间是否存在显著的统计学差异。
这项比较研究于2022年8月至2024年7月在印度浦那的D.Y.帕蒂尔医学院、医院和研究中心放射诊断科进行。该研究包括60名参与者，分为两组：30名单纯性高血压患者和30名正常孕妇。使用三星HS70A超声机（三星电子私人有限公司，韩国首尔）测量胎盘硬度，并使用曲线探头进行pSWE检查。使用IBM SPSS Statistics for Windows 21版（2012年发布；IBM公司，美国纽约阿蒙克）分析数据，两组之间差异的显著性使用独立t检验进行评估，p值<0.05被认为具有统计学意义。
与健康组（3.36±0.66千帕）相比，子痫前期组以千帕（kPa）为单位测量得到的平均胎盘硬度显著更高（11.71±1.故，剪切波弹性成像可作为辅助子痫前期诊断/预测的补充工具。 52千帕）（p = 0.001）。发现患有子痫前期的患者胎盘硬度水平显著更高。
早期诊断仍然是管理子痫前期的关键，以便为患者提供充分的监测和治疗。我们的研究表明，与健康胎盘相比，子痫前期患者的胎盘硬度存在显著的统计学差异。因
