Khakhar Zamanali, Manji Soraiya, Patel Rajiv, Sharma Karishma, Waa Sheila, Ali Sayed K
Department of Medicine, University of Nairobi, Nairobi, KEN.
Department of Internal Medicine, Aga Khan University Hospital, Nairobi, KEN.
Cureus. 2024 Sep 3;16(9):e68519. doi: 10.7759/cureus.68519. eCollection 2024 Sep.
Leptomeningeal carcinomatosis (LMC) is a rare and fatal complication associated with various solid tumors and hematological malignancies. It presents significant diagnostic challenges due to its nonspecific symptoms and complex clinical course. This case report details the presentation, diagnosis, and implications of LMC in a 33-year-old male with a history of colorectal cancer (CRC) and hemicolectomy. The patient presented with nonspecific symptoms of headache and dizziness. Cerebrospinal fluid cytology revealed the presence of malignant cells, leading to the diagnosis of LMC secondary to CRC. The elusive and multifaceted nature of this condition highlights the necessity for increased clinical awareness and extensive research to improve the understanding and management of LMC.
软脑膜癌病(LMC)是一种与多种实体瘤和血液系统恶性肿瘤相关的罕见且致命的并发症。由于其非特异性症状和复杂的临床病程,它带来了重大的诊断挑战。本病例报告详细介绍了一名33岁有结肠癌(CRC)病史并接受过半结肠切除术的男性患者的LMC表现、诊断及影响。患者出现头痛和头晕等非特异性症状。脑脊液细胞学检查发现恶性细胞,从而诊断为继发于CRC的LMC。这种疾病难以捉摸且具有多面性,凸显了提高临床认识和进行广泛研究以增进对LMC的理解和管理的必要性。