印戒细胞型结肠腺癌以软脑膜转移为首发表现：1例病例报告并文献复习
Leptomeningeal metastasis as initial manifestation of signet ring colorectal adenocarcinoma: a case report with review of literature.
作者信息
Assi Rita, Hamieh Lana, Mukherji Deborah, Haydar Ali, Temraz Sally, El-Dika Imane, Shamseddine Ali
机构信息
1 Department of Internal Medicine, Division of Hematology-Oncology, 2 Department of Radiology, American University of Beirut Medical Center, Beirut 1103, Lebanon.
出版信息
J Gastrointest Oncol. 2015 Dec;6(6):E89-E101. doi: 10.3978/j.issn.2078-6891.2015.087.
Abstract
Leptomeningeal carcinomatosis (LMC) is an exceedingly rare event especially as a first manifestation of an occult primary colorectal cancer and even when there is a known history of malignancy. Sensorineural hearing loss is by itself an unusual isolated presentation of LMC with unsolved pathophysiology in this setting. In this paper, we report such a case and review the literature for similar cases, focusing on postulated mechanisms of spread. In view of the poor prognosis they carry, we highly recommend that physicians be aware of the risk of rare metastasis from colorectal adenocarcinoma in order to establish an early confirmative diagnosis.
摘要
软脑膜癌病（LMC）是一种极其罕见的情况，尤其是作为隐匿性原发性结直肠癌的首发表现，即便存在已知恶性肿瘤病史时亦是如此。在这种情况下，感音神经性听力损失本身就是LMC一种不常见的孤立表现，其病理生理学尚未明确。在本文中，我们报告了这样一例病例，并回顾了类似病例的文献，重点关注推测的扩散机制。鉴于其预后较差，我们强烈建议医生了解结直肠腺癌罕见转移的风险，以便尽早做出确诊。
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