一种具有六个Fe(III)中心的八面体配位笼作为磁共振成像（MRI）探针。

An octahedral coordination cage with six Fe(III) centers as a MRI probe.

作者信息

Dissanayake Aruni, Spernyak Joseph A, Morrow Janet R

机构信息

Department of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.

Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, USA.

出版信息

Chem Commun (Camb). 2024 Oct 17;60(84):12249-12252. doi: 10.1039/d4cc03681f.

DOI:10.1039/d4cc03681f

PMID:39364604

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11450543/

Abstract

The incorporation of multiple Fe(III) centers bridged by rigid ligands into a coordination cage represents a powerful approach for designing effective MRI contrast agents. In this context, an octahedral coordination cage with six high-spin Fe(III) centers is shown to be water soluble, robust towards dissociation and has effective relaxivity as a MRI probe in solution and in mice.

摘要

将多个由刚性配体桥联的Fe(III)中心整合到一个配位笼中是设计有效磁共振成像（MRI）造影剂的一种有效方法。在这种情况下，一种具有六个高自旋Fe(III)中心的八面体配位笼被证明是水溶性的，抗解离能力强，并且在溶液中和小鼠体内作为MRI探针具有有效的弛豫率。