Vasiljevic Zorana, Zlatic Natasa, Rajic Dubravka, Mitrovic Predrag, Viduljevic Mihajlo, Matic Dragan, Asanin Milika, Stankovic Sanja
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Cardiology Intensive Care Unit, Emergency Department, Clinic for Cardiology, University Clinical Center of Serbia, Belgrade, Serbia.
Curr Pharm Des. 2025;31(6):484-492. doi: 10.2174/0113816128326875240916050251.
The current study aims to investigate the blood Hcy levels in patients with CAD and hypertension in Serbia, a country with a high incidence and mortality of both diseases.
The level of Hcy in the Serbian population was assessed in 123 patients with chronic coronary artery disease (CAD) and hypertension. There were 53 patients with chronic CAD and 70 patients with hypertension (HTA), but without CAD.
The Hcy levels were high in both groups of patients (the mean Hcy level of 16.0 ± 7.0 μmol/L) without a statistical difference between the patients in the CAD (14.9 ± 7.3 μmol/L) and hypertension (16.7 ± 6.7 μmol/L) groups. Hypercholesterolemia was found in 81% of the patients with CAD and 92.0% of the patients with HTA, as a common concern across both clinical conditions. It was also found that not a single conventional risk factor (diabetes, hypertension, the smoking status, the family history of CAD, and hyperlipidemia) may individually influence Hcy levels. By contrast, the low levels of vitamin B12 may be related to the high levels of Hcy.
Given the fact that it is known that various factors interact and influence Hcy levels and associated cardiovascular risks, specific dietary habits, lifestyle and the other Serbia-specific possible factors were done.
当前研究旨在调查塞尔维亚冠心病和高血压患者的血液同型半胱氨酸（Hcy）水平，该国这两种疾病的发病率和死亡率都很高。
对123例慢性冠状动脉疾病（CAD）和高血压患者的塞尔维亚人群Hcy水平进行评估。其中有53例慢性CAD患者和70例高血压（HTA）患者，但无CAD。
两组患者的Hcy水平均较高（平均Hcy水平为16.0±7.0μmol/L），CAD组（14.9±7.3μmol/L）和高血压组（16.7±6.7μmol/L）患者之间无统计学差异。81%的CAD患者和92.0%的HTA患者存在高胆固醇血症，这是两种临床情况的共同关注点。还发现没有单一的传统危险因素（糖尿病、高血压、吸烟状况、CAD家族史和高脂血症）可单独影响Hcy水平。相比之下，维生素B12水平低可能与Hcy水平高有关。
鉴于已知多种因素相互作用并影响Hcy水平及相关心血管风险，研究了特定饮食习惯、生活方式及塞尔维亚其他可能的因素。
