Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY 14853.
Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2415231121. doi: 10.1073/pnas.2415231121. Epub 2024 Oct 4.
I had my eyes set on DNA replication research when I took my first molecular biology course in graduate school. My election to the National Academy of Sciences came just when I was retiring from active research. It gives me an opportunity to reflect on my personal journey in eukaryotic DNA replication research, which started as a thought experiment and culminated in witnessing the determination of the cryoelectron microscopic structure of the yeast replisome in the act of transferring histone-encoded epigenetic information at the replication fork. I would like to dedicate this inaugural article to my talented trainees and valuable collaborators in gratitude for the joy they gave me in this journey. I also want to thank my mentors who instilled in me the purpose of science. I hope junior scientists will not be disheartened by the marathon nature of research, but mindful enough to integrate and pause for other equally fun and meaningful activities of life into the marathon.
当我在研究生院上第一门分子生物学课时，我就把目光投向了 DNA 复制研究。我当选为美国国家科学院院士正值我从活跃的研究中退休之时。这让我有机会回顾自己在真核 DNA 复制研究方面的个人历程，这个历程始于一个思想实验，最终见证了冷冻电子显微镜结构在复制叉处转移组蛋白编码表观遗传信息的酵母复制体的确定。我想将这篇首发文章献给我有才华的受训者和有价值的合作者，感谢他们在这段旅程中给我带来的快乐。我也要感谢我的导师，他们给了我科学的目的。我希望年轻的科学家不要因为研究的马拉松性质而灰心丧气，而是要足够明智，将同样有趣和有意义的生活活动融入到马拉松中。
