Department of Biomedical Engineering, Technion - IIT, Haifa 32000, Israel.
Department of Radiology, New England Center for Stroke Research, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Sci Adv. 2024 Oct 4;10(40):eadp4579. doi: 10.1126/sciadv.adp4579.
Current approaches for localized intravascular treatments rely on using solid implants, such as metallic coils for embolizing aneurysms, or on direct injection of a therapeutic agent that can disperse from the required site of action. Here, we present a fluid-based strategy for localizing intravascular therapeutics that leverages surface tension and immiscible fluid interactions, to allow confined and focal treatment at brain aneurysm sites. We first show, computationally and experimentally, that an immiscible phase can be robustly positioned at the neck of human aneurysm models to seal and isolate the aneurysm's cavity for further treatment, including in wide-neck aneurysms. We then demonstrate localized delivery and confined treatment, by selective staining of cell nuclei within the aneurysm cavity as well as by hydrogel-based embolization in patient-specific aneurysm models. Altogether, our interfacial flow-driven strategy offers a potential approach for intravascular localized treatment of cardiovascular and other diseases.
目前针对局部血管内治疗的方法依赖于使用固体植入物，例如用于栓塞动脉瘤的金属线圈，或直接注射可以从所需作用部位扩散的治疗剂。在这里，我们提出了一种基于流体的血管内治疗定位策略，利用表面张力和不混溶流体相互作用，以允许在脑动脉瘤部位进行受限和聚焦治疗。我们首先通过计算和实验表明，一种不混溶相可以在人体动脉瘤模型的颈部稳定地定位，以密封和隔离动脉瘤的腔，从而进行进一步的治疗，包括在宽颈动脉瘤中。然后，我们通过选择性地对动脉瘤腔内的细胞核进行染色，以及在患者特定的动脉瘤模型中进行基于水凝胶的栓塞，证明了局部递送和受限治疗。总的来说，我们的界面流驱动策略为血管内局部治疗心血管疾病和其他疾病提供了一种潜在的方法。
