Ko Giho, Choi Jin Woo, Lee Nohyun, Kim Dokyoon, Hyeon Taeghwan, Kim Hyo-Cheol
Center for Nanoparticle Research, Institute for Basic Spegcience (IBS), Seoul 08826, Republic of Korea; School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Biomaterials. 2022 Aug;287:121634. doi: 10.1016/j.biomaterials.2022.121634. Epub 2022 Jun 13.
Vascular embolization is a non-surgical procedure used to treat diseases or morbid conditions related to blood vessels, such as bleeding, arteriovenous malformation, aneurysm, and hypervascular tumors, through the intentional occlusion of blood vessels. Among various types of embolic agents that have been applied, liquid embolic agents are gaining an increasing amount of attention owing to their advantages in distal infiltration into regions where solid embolic agents cannot reach, enabling more extensive embolization. Meanwhile, recent advances in biomaterials and technologies have also contributed to the development of novel liquid embolic agents that can resolve the challenges faced while using the existing embolic materials. In this review, we briefly summarize the clinically used embolic agents and their applications, and then present selected research results that overcome the limitations of the embolic agents in use. Through this review, we suggest the required properties of liquid embolic agents that ensure efficacy, which can replace the existing agents, providing directions for the future development in this field.
血管栓塞术是一种非手术治疗方法，通过故意阻塞血管来治疗与血管相关的疾病或病态状况，如出血、动静脉畸形、动脉瘤和富血管肿瘤。在已应用的各类栓塞剂中，液体栓塞剂因其能够向固体栓塞剂无法到达的区域进行远端渗透的优势，从而实现更广泛的栓塞，正受到越来越多的关注。与此同时，生物材料和技术的最新进展也推动了新型液体栓塞剂的开发，这些新型栓塞剂能够解决使用现有栓塞材料时所面临的挑战。在本综述中，我们简要总结了临床使用的栓塞剂及其应用，然后展示了一些克服现有栓塞剂局限性的研究成果。通过本综述，我们提出了确保疗效的液体栓塞剂所需具备的特性，这些特性可替代现有栓塞剂，为该领域的未来发展提供方向。
