Perfeito Francisca G, Vilabril Sara, Cerqueira Andreia, Oliveira Mariana B, Mano João F
Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, 3810-193, Portugal.
Adv Sci (Weinh). 2024 Dec;11(45):e2402592. doi: 10.1002/advs.202402592. Epub 2024 Oct 4.
Multicompartmental capsules have demonstrated value in fields ranging from drug release, mimetics of artificial cells, to energy conversion and storage. However, the fabrication of devices with different compartments usually requires the use of toxic solvents, and/or the adaptation of technically demanding methods, including precision microfluidics and multistep processes. The spontaneous formation of multi-core capsules resulting from polyelectrolyte complexation at the interface of a prototypic all-aqueous two-phase system is described here. The variation of polyelectrolyte concentration and complexation time are described as simple working parameters capable of driving the formation of compartments at different yields, as well as tailoring their morphology. The mild processing technology enables the encapsulation of animal cells, which are capable of invading capsule walls for specific processing conditions.
多隔室胶囊已在从药物释放、人工细胞模拟到能量转换与存储等诸多领域展现出价值。然而，制造具有不同隔室的装置通常需要使用有毒溶剂，和/或采用技术要求较高的方法，包括精密微流体技术和多步工艺。本文描述了在原型全水两相系统界面处通过聚电解质络合自发形成多核胶囊的过程。聚电解质浓度和络合时间的变化被描述为能够以不同产率驱动隔室形成并调整其形态的简单工作参数。这种温和的加工技术能够封装动物细胞，在特定加工条件下这些细胞能够侵入胶囊壁。
