历经 50 年的探索：含氨基酸的核苷 acpU 将 N-糖链与 glycoRNA 中的 RNA 连接起来。
50 years in the making: acpU, an amino-acid-containing nucleoside, links N-glycans and RNA in glycoRNA.
机构信息
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
出版信息
Mol Cell. 2024 Oct 3;84(19):3576-3577. doi: 10.1016/j.molcel.2024.09.014.
Abstract
In a recent publication in Cell, Xie et al. report a sensitive and scalable method for the detection and characterization of native glycoRNAs and identify acpU, an abundant modified nucleoside discovered 50 years ago in tRNA, as one of the primary attachment sites for N-glycans.
摘要
在最近发表在《Cell》上的一项研究中，谢等人报道了一种用于检测和表征天然糖 RNA 的灵敏且可扩展的方法，并鉴定出 acpU，这是一种在 tRNA 中发现的 50 年前的丰富修饰核苷，是 N-糖基化的主要附着位点之一。
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