PRC2-RNA 相互作用：来自 YongWoo Lee 和 Jeannie T. Lee 的观点。

PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee.

机构信息

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

出版信息

Mol Cell. 2024 Oct 3;84(19):3586-3592. doi: 10.1016/j.molcel.2024.09.006.

DOI:10.1016/j.molcel.2024.09.006

PMID:39366347

Abstract

Here, we expound on the view that Xist RNA directly controls Polycomb repressive complex 2 (PRC2) recruitment, off-loading to chromatin, catalytic activity, and eviction from chromatin. RNA-PRC2 interactions also control RNA polymerase II transcription pausing. Dynamic RNA folding determines PRC2 activity. Disparate studies and interpretations abound but can be reconciled.

摘要

在这里，我们阐述了这样一种观点，即 Xist RNA 直接控制多梳抑制复合物 2（PRC2）的募集、向染色质的卸载、催化活性以及从染色质中的逐出。RNA-PRC2 相互作用还控制 RNA 聚合酶 II 转录暂停。动态 RNA 折叠决定了 PRC2 的活性。虽然存在着大量不同的研究和解释，但它们可以得到协调。